topicInosine Exercise Performance Meta-Analysis
claimPurpose This study aimed to identify candidate acute exercise-responsive metabolic biomarkers associated with physical fatigue assessment by integrating conventional biomarker evidence, exercise-related metabolomics, and exploratory targeted Liquid chromatography-mass spectrometry (LC-MS) analysis.
evidence level1
citationHuang L (2026)
sourceCandidate Metabolic Biomarkers for Physical Fatigue Assessment: An Integrative Meta-Analysis and Exploratory Liquid Chromatography-Mass Spectrometry Pilot Study of Acute Exercise Responses.
topicInosine Exercise Performance Meta-Analysis
claimConclusions Lactate, pyruvate, hypoxanthine, and xanthine represent candidate metabolism-based acute exercise-responsive biomarkers associated with physical fatigue.
evidence level1
citationHuang L (2026)
sourceCandidate Metabolic Biomarkers for Physical Fatigue Assessment: An Integrative Meta-Analysis and Exploratory Liquid Chromatography-Mass Spectrometry Pilot Study of Acute Exercise Responses.
topicInosine Exercise Performance Meta-Analysis
claimBackground Objective body-fluid biomarkers may help characterize exercise-induced physical fatigue; however, heterogeneity in exercise protocols, biological matrices, and analytical platforms complicates biomarker interpretation.
evidence level1
citationHuang L (2026)
sourceCandidate Metabolic Biomarkers for Physical Fatigue Assessment: An Integrative Meta-Analysis and Exploratory Liquid Chromatography-Mass Spectrometry Pilot Study of Acute Exercise Responses.
topicInosine Exercise Performance Meta-Analysis
claimWe examined whether the AMPD1 C34T (rs17602729) genotype was associated with athlete status and performance in distance runners (DRs) and rugby union (RU) athletes.
evidence level4
citationMartin DR (2026)
sourceDoes the <i>AMPD1</i> C34T Polymorphism Influence Physical Performance in Elite Athletes?
topicInosine Exercise Performance Meta-Analysis
claimConclusions : In summary, while the AMPD1 C34T genotype was not associated with athlete status, the CC genotype was associated with greater RU playing time per appearance in forwards, and the CT genotype was associated with superior performance in elite DRs.
evidence level4
citationMartin DR (2026)
sourceDoes the <i>AMPD1</i> C34T Polymorphism Influence Physical Performance in Elite Athletes?
topicInosine Exercise Performance Meta-Analysis
claimBackground/Objectives : Adenosine monophosphate deaminase deficiency has been implicated in impaired exercise capacity.
evidence level4
citationMartin DR (2026)
sourceDoes the <i>AMPD1</i> C34T Polymorphism Influence Physical Performance in Elite Athletes?