evidence table

Hyaluronic Skin Aging Randomized Trial Evidence Table

Structured evidence table for Hyaluronic Skin Aging Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Hyaluronic Skin Aging Randomized TrialIn accordance with EMA Committee for Advanced Therapies (EMA-CAT) recommendations (Guideline on Human Cell-Based Medicinal Products, 2015, section 2.2.4a), this approach qualifies as a “technique, since the processing does not alter the biological characteristics, physiological functions, or structural properties of the cells.2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Skin Aging Randomized Trial20 patients with mild to moderate dermal thinning, reduced elasticity, and wrinkles were assigned to the study group (SG) and treated with Am-FBs (A–C).2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Skin Aging Randomized TrialThe Risk Evaluation and Mitigation Strategies (REMSs) incorporating Elements to Assure Safe Use (ETASU) were applied in Am-FBs and HA-based skin booster treatments, significantly reducing safety-related risks.2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Skin Aging Randomized Trial, , , The natural aging process leads to the degradation of the dermal extracellular matrix (ECM), decreased fibroblast activity, and a loss of skin elasticity.Traditional cosmetic procedures, such as hyaluronic acid (HA)-based skin boosters, provide temporary benefits, but autologous cell-based therapies offer a biologically driven regenerative approach.2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Skin Aging Randomized TrialCollagen, along with antioxidants such as curcumin and glutathione, have gained increased utilization/awareness in recent years, providing dermal health benefits especially in women who experience declining or loss of estrogen with aging.4Arbex Priscila (2026)Collagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
Hyaluronic Skin Aging Randomized TrialThe evidence of oral collagen as a nutraceutical is robust for improving several aspects of dermal health.4Arbex Priscila (2026)Collagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
Hyaluronic Skin Aging Randomized TrialFor example, the epidermis is without a blood supply and does not have the same circulation and nutrient delivery found in the dermis [–].4Arbex Priscila (2026)Collagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
Hyaluronic Skin Aging Randomized TrialThe present narrative review is an extension of a larger project that covered polyphenols and phytoestrogens.4Arbex Priscila (2026)Collagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicHyaluronic Skin Aging Randomized Trial
claimIn accordance with EMA Committee for Advanced Therapies (EMA-CAT) recommendations (Guideline on Human Cell-Based Medicinal Products, 2015, section 2.2.4a), this approach qualifies as a “technique, since the processing does not alter the biological characteristics, physiological functions, or structural properties of the cells.
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Skin Aging Randomized Trial
claim20 patients with mild to moderate dermal thinning, reduced elasticity, and wrinkles were assigned to the study group (SG) and treated with Am-FBs (A–C).
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Skin Aging Randomized Trial
claimThe Risk Evaluation and Mitigation Strategies (REMSs) incorporating Elements to Assure Safe Use (ETASU) were applied in Am-FBs and HA-based skin booster treatments, significantly reducing safety-related risks.
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Skin Aging Randomized Trial
claim, , , The natural aging process leads to the degradation of the dermal extracellular matrix (ECM), decreased fibroblast activity, and a loss of skin elasticity.Traditional cosmetic procedures, such as hyaluronic acid (HA)-based skin boosters, provide temporary benefits, but autologous cell-based therapies offer a biologically driven regenerative approach.
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Skin Aging Randomized Trial
claimCollagen, along with antioxidants such as curcumin and glutathione, have gained increased utilization/awareness in recent years, providing dermal health benefits especially in women who experience declining or loss of estrogen with aging.
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicHyaluronic Skin Aging Randomized Trial
claimThe evidence of oral collagen as a nutraceutical is robust for improving several aspects of dermal health.
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicHyaluronic Skin Aging Randomized Trial
claimFor example, the epidermis is without a blood supply and does not have the same circulation and nutrient delivery found in the dermis [–].
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review
topicHyaluronic Skin Aging Randomized Trial
claimThe present narrative review is an extension of a larger project that covered polyphenols and phytoestrogens.
evidence level4
citationArbex Priscila (2026)
sourceCollagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review

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Source documents

  1. Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
  2. Collagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels —A Narrative Review