topicHmb Resistance Training Meta-Analysis
claimThe Grading of Recommendations Assessment, Development, and Evaluation, Tool for the assEssment of Study qualiTy and reporting in EXercise, Rob 2, and Preferred Reporting Items for Systematic reviews and Meta-Analyses tools were used to evaluate the methodological quality and certainty of evidence.
evidence level1
citationHernandez-Martinez J (2026)
sourceCombined effects of strength training, whey protein, and HMB on sarcopenia in older people: A systematic review and meta-analysis.
topicHmb Resistance Training Meta-Analysis
claimFour overall meta-analysis showed significant increases (P Conclusion ST combined with WP or HMB supplementation may contribute to improvements in fat-free mass and selected physical performance outcomes in older people with sarcopenia.
evidence level1
citationHernandez-Martinez J (2026)
sourceCombined effects of strength training, whey protein, and HMB on sarcopenia in older people: A systematic review and meta-analysis.
topicHmb Resistance Training Meta-Analysis
claimHowever, the limited number of RCTs, relatively small sample sizes, moderate-to-high risk of bias, and inconsistent subgroup findings indicate that the current evidence should be interpreted cautiously and considered promising rather than definitive.
evidence level1
citationHernandez-Martinez J (2026)
sourceCombined effects of strength training, whey protein, and HMB on sarcopenia in older people: A systematic review and meta-analysis.
topicHmb Resistance Training Meta-Analysis
claimBackground Although previous studies have reported the benefits of combining physical activity with supplementation on body composition and physical performance in older people with sarcopenia, previous meta-analysis often included heterogeneous interventions, combining multiple types of supplements.
evidence level1
citationHernandez-Martinez J (2026)
sourceCombined effects of strength training, whey protein, and HMB on sarcopenia in older people: A systematic review and meta-analysis.
topicHmb Resistance Training Meta-Analysis
claimObjective This systematic review and network meta-analysis compared the additional effects of different protein or protein-related supplementation strategies combined with resistance or functional exercise on grip strength, appendicular skeletal muscle mass index (ASMI), and timed up-and-go (TUG) performance in older adults with sarcopenia or at high risk of sarcopenia.
evidence level1
citationYang B (2026)
sourceComparative effectiveness of protein or protein-related supplementation combined with resistance or functional exercise for sarcopenia in older adults: a systematic review and network meta-analysis.
topicHmb Resistance Training Meta-Analysis
claimPairwise meta-analysis showed that supplementation added to exercise significantly improved grip strength (SMD = 0.39, 95% CI: 0.20 to 0.58) and ASMI (SMD = 0.18, 95% CI: 0.00 to 0.35), but not timed up-and-go (TUG) performance (SMD = -0.39, 95% CI: -0.96 to 0.18).
evidence level1
citationYang B (2026)
sourceComparative effectiveness of protein or protein-related supplementation combined with resistance or functional exercise for sarcopenia in older adults: a systematic review and network meta-analysis.
topicHmb Resistance Training Meta-Analysis
claimThe combination of whey protein/essential amino acids and vitamin D with functional exercise showed a potential improvement in TUG performance; however, this finding was based on limited evidence and may largely reflect the contribution of functional exercise components.
evidence level1
citationYang B (2026)
sourceComparative effectiveness of protein or protein-related supplementation combined with resistance or functional exercise for sarcopenia in older adults: a systematic review and network meta-analysis.
topicHmb Resistance Training Meta-Analysis
claimBackground Resistance and functional exercise are core non-pharmacological strategies for sarcopenia management.
evidence level1
citationYang B (2026)
sourceComparative effectiveness of protein or protein-related supplementation combined with resistance or functional exercise for sarcopenia in older adults: a systematic review and network meta-analysis.