Structured evidence table for Hmb Muscle Strength Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Hmb Muscle Strength Randomized Trial | 1 2 3 4 5 Older age is associated with declines in skeletal muscle mass, strength and function, termed sarcopenia []. | 2 | Smith Kenneth (2026) | The Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A Randomized Double-Blind Controlled Crossover Clinical Trial |
| Hmb Muscle Strength Randomized Trial | Involving motor unit remodelling and muscle fibre atrophy as a result of lifestyle, genetic and disease interactions, sarcopenia is a major hurdle to improving health-span against the backdrop of increasing lifespan. | 2 | Smith Kenneth (2026) | The Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A Randomized Double-Blind Controlled Crossover Clinical Trial |
| Hmb Muscle Strength Randomized Trial | While the underlying mechanisms leading to anabolic resistance remain ill-defined, impaired digestion/absorption [], increased AA splanchnic uptake [], muscle microvascular dysfunction [], and myocellular cell signalling deficits [] have all been reported. | 2 | Smith Kenneth (2026) | The Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A Randomized Double-Blind Controlled Crossover Clinical Trial |
| Hmb Muscle Strength Randomized Trial | Such redox dysregulation has been associated with lower strength, impaired endurance, and reduced adaptive responses to exercise (Powers et al.). | 2 | Ramos-Hernández Rafael (2026) | Creatine plus β-Hydroxy-β-Methylbutyrate supplementation is associated with preserved glutathione redox-balance and redox–function associations in older adults: a secondary analysis of a randomized crossover trial |
| Hmb Muscle Strength Randomized Trial | 2024 2019 2020a b 2025 A growing body of evidence indicates that HMB may influence oxidative metabolism and mitochondrial function, with meta-analytic data showing improvements in endurance performance and aerobic capacity (Fernández-Landa et al.). | 2 | Ramos-Hernández Rafael (2026) | Creatine plus β-Hydroxy-β-Methylbutyrate supplementation is associated with preserved glutathione redox-balance and redox–function associations in older adults: a secondary analysis of a randomized crossover trial |
| Hmb Muscle Strength Randomized Trial | A secondary exploratory objective was to assess whether changes in redox indices were associated with changes in muscle strength and functional performance, whose absolute values were previously published for this cohort. | 2 | Ramos-Hernández Rafael (2026) | Creatine plus β-Hydroxy-β-Methylbutyrate supplementation is associated with preserved glutathione redox-balance and redox–function associations in older adults: a secondary analysis of a randomized crossover trial |
| Hmb Muscle Strength Randomized Trial | 2019 2016 Aging is characterized by progressive declines in skeletal muscle quality and functional capacity that diminish mobility and quality of life (Cruz-Jentoft et al.). | 2 | Ramos-Hernández Rafael (2026) | Creatine plus β-Hydroxy-β-Methylbutyrate supplementation is associated with preserved glutathione redox-balance and redox–function associations in older adults: a secondary analysis of a randomized crossover trial |
Source documents