topicHmb Muscle Mass Randomized Trial
claimConclusion Acute post-exercise HMB-FA supplementation in elite judo athletes did not significantly influence muscle damage or oxidative stress markers but transiently increased antioxidant enzyme activities (CAT, GPX, and SOD).
evidence level2
citationTayebi SM (2026)
sourceEffects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial.
topicHmb Muscle Mass Randomized Trial
claimPurpose High-intensity judo bouts induce oxidative stress and muscle damage, impairing recovery.
evidence level2
citationTayebi SM (2026)
sourceEffects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial.
topicHmb Muscle Mass Randomized Trial
claimThis randomized, double-blind, placebo-controlled pilot trial examined whether acute β -hydroxy- β -methylbutyrate free acid (HMB-FA) supplementation influences muscle damage, oxidative stress, and antioxidant biomarkers in elite judoka.
evidence level2
citationTayebi SM (2026)
sourceEffects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial.
topicHmb Muscle Mass Randomized Trial
claim1 2 3 4 5 Older age is associated with declines in skeletal muscle mass, strength and function, termed sarcopenia [].
evidence level2
citationSmith Kenneth (2026)
sourceThe Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A Randomized Double-Blind Controlled Crossover Clinical Trial
topicHmb Muscle Mass Randomized Trial
claimInvolving motor unit remodelling and muscle fibre atrophy as a result of lifestyle, genetic and disease interactions, sarcopenia is a major hurdle to improving health-span against the backdrop of increasing lifespan.
evidence level2
citationSmith Kenneth (2026)
sourceThe Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A Randomized Double-Blind Controlled Crossover Clinical Trial
topicHmb Muscle Mass Randomized Trial
claimWhile the underlying mechanisms leading to anabolic resistance remain ill-defined, impaired digestion/absorption [], increased AA splanchnic uptake [], muscle microvascular dysfunction [], and myocellular cell signalling deficits [] have all been reported.
evidence level2
citationSmith Kenneth (2026)
sourceThe Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A Randomized Double-Blind Controlled Crossover Clinical Trial