topicHesperidin Supplementation Vascular Function Meta-Analysis
claimAdipose tissue expansion, immune cell infiltration, adipokine dysregulation, mitochondrial dysfunction, and increased reactive oxygen species generation collectively promote metabolic and vascular abnormalities including insulin resistance, fatty liver, vascular endothelial activation, and atherosclerosis (–).
evidence level1
citationZhu Kun (2026)
sourceEffects of hesperidin supplementation on inflammation and oxidative stress in overweight or obese individuals: a systematic review and meta-analysis of randomized controlled trials
topicHesperidin Supplementation Vascular Function Meta-Analysis
claimConstructing an outcome hierarchy based on these complementary readouts better captures the pathological features associated with overweight and obesity than emphasizing a single inflammatory biomarker alone.
evidence level1
citationZhu Kun (2026)
sourceEffects of hesperidin supplementation on inflammation and oxidative stress in overweight or obese individuals: a systematic review and meta-analysis of randomized controlled trials
topicHesperidin Supplementation Vascular Function Meta-Analysis
claimExperimental evidence suggests that hesperidin and its aglycone metabolite hesperetin may modulate inflammatory and oxidative pathways, providing biological plausibility for effects on inflammatory and oxidative stress biomarkers (–).
evidence level1
citationZhu Kun (2026)
sourceEffects of hesperidin supplementation on inflammation and oxidative stress in overweight or obese individuals: a systematic review and meta-analysis of randomized controlled trials
topicHesperidin Supplementation Vascular Function Meta-Analysis
claim1 4 Overweight and obesity are not merely anthropometric states but are commonly accompanied by low-grade chronic inflammation, redox imbalance, and metabolic tissue stress.
evidence level1
citationZhu Kun (2026)
sourceEffects of hesperidin supplementation on inflammation and oxidative stress in overweight or obese individuals: a systematic review and meta-analysis of randomized controlled trials
topicHesperidin Supplementation Vascular Function Meta-Analysis
claimPhysical training reduced the body weight gain and fat accumulation and modulated the oxidative status by increasing superoxide dismutase activity and total antioxidant capacity and reducing lipid peroxidation.
evidence level4
citationGonçalves TT (2018)
sourceEffects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet.
topicHesperidin Supplementation Vascular Function Meta-Analysis
claimPotency of sodium nitroprusside was increased in exercised animals but not in GH-supplemented rats.
evidence level4
citationGonçalves TT (2018)
sourceEffects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet.
topicHesperidin Supplementation Vascular Function Meta-Analysis
claimConclusion Physical exercise partially decreased the body fat accumulation, decreased plasma levels of glucose and lipids and improved general oxidative status and endothelium-independent relaxation in mesenteric arteries of rats fed with HFD.
evidence level4
citationGonçalves TT (2018)
sourceEffects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet.
topicHesperidin Supplementation Vascular Function Meta-Analysis
claimObjective The aim of the study was to evaluate the effects of supplementation with glucosyl hesperidin (GH), with or without physical training, on body weight, fat depot, glucose and plasma lipids, oxidative status and vascular function of rats fed with high-fat diet (HFD).
evidence level4
citationGonçalves TT (2018)
sourceEffects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet.