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Hesperidin Supplement Endothelial Function Randomized Trial Evidence Table

Structured evidence table for Hesperidin Supplement Endothelial Function Randomized Trial, generated from 1 reusable source document in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Hesperidin Supplement Endothelial Function Randomized Trial1 2 3 4 5 7 8 9 10 11 12 Cardiovascular disease (CVD) is a major cause of mortality worldwide, accounting for 32% of deaths in the United States and United Kingdom, with men being at a higher risk than women (,).2Schär Manuel Y (2015)Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease 1 2 3 4 5
Hesperidin Supplement Endothelial Function Randomized TrialIn support of this, epidemiologic data provide evidence to suggest that flavanones and intake of citrus fruit are inversely associated with CVD mortality (–).2Schär Manuel Y (2015)Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease 1 2 3 4 5
Hesperidin Supplement Endothelial Function Randomized TrialIn addition, animal and in vitro studies have reported that flavanones improve endothelial function [principally via enhanced production or reduced NADPH oxidase-dependent elimination of endothelial nitric oxide (,)] and cardiac autonomic function (), as well as reduce blood pressure () and platelet reactivity ().2Schär Manuel Y (2015)Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease 1 2 3 4 5
Hesperidin Supplement Endothelial Function Randomized TrialRecent data suggest that diets rich in fruit were the third most important modifiable factor for reducing global CVD-related morbidity and mortality, with only blood pressure–lowering medication and smoking cessation having greater effects ().2Schär Manuel Y (2015)Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease 1 2 3 4 5
topicHesperidin Supplement Endothelial Function Randomized Trial
claim1 2 3 4 5 7 8 9 10 11 12 Cardiovascular disease (CVD) is a major cause of mortality worldwide, accounting for 32% of deaths in the United States and United Kingdom, with men being at a higher risk than women (,).
evidence level2
citationSchär Manuel Y (2015)
sourceOrange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease 1 2 3 4 5
topicHesperidin Supplement Endothelial Function Randomized Trial
claimIn support of this, epidemiologic data provide evidence to suggest that flavanones and intake of citrus fruit are inversely associated with CVD mortality (–).
evidence level2
citationSchär Manuel Y (2015)
sourceOrange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease 1 2 3 4 5
topicHesperidin Supplement Endothelial Function Randomized Trial
claimIn addition, animal and in vitro studies have reported that flavanones improve endothelial function [principally via enhanced production or reduced NADPH oxidase-dependent elimination of endothelial nitric oxide (,)] and cardiac autonomic function (), as well as reduce blood pressure () and platelet reactivity ().
evidence level2
citationSchär Manuel Y (2015)
sourceOrange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease 1 2 3 4 5
topicHesperidin Supplement Endothelial Function Randomized Trial
claimRecent data suggest that diets rich in fruit were the third most important modifiable factor for reducing global CVD-related morbidity and mortality, with only blood pressure–lowering medication and smoking cessation having greater effects ().
evidence level2
citationSchär Manuel Y (2015)
sourceOrange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease 1 2 3 4 5

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Source documents

  1. Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease 1 2 3 4 5