topicGreen Tea Stress Randomized Trial
claimThis transition results from the progressive depletion of ovarian follicles, leading to reduced estrogen and progesterone secretion [].
evidence level1
citationZago Isabella Heloísa Rodrigues (2026)
sourceEffects of green tea use on the metabolic profile of postmenopausal women: systematic review and meta-analysis
topicGreen Tea Stress Randomized Trial
claimThese changes are associated with an increased risk of several chronic conditions, including cardiovascular disease, hormone-sensitive breast cancer, insulin resistance, type 2 diabetes mellitus (T2DM), and osteoporosis.
evidence level1
citationZago Isabella Heloísa Rodrigues (2026)
sourceEffects of green tea use on the metabolic profile of postmenopausal women: systematic review and meta-analysis
topicGreen Tea Stress Randomized Trial
claim5 6 Sleep disturbances, emotional lability, depression, and anxiety are also frequently reported during the menopausal transition, along with reduced libido and cognitive decline [].
evidence level1
citationZago Isabella Heloísa Rodrigues (2026)
sourceEffects of green tea use on the metabolic profile of postmenopausal women: systematic review and meta-analysis
topicGreen Tea Stress Randomized Trial
claim1 2 Menopause is retrospectively defined as the absence of menstruation for 12 consecutive months and marks the end of female reproductive function.
evidence level1
citationZago Isabella Heloísa Rodrigues (2026)
sourceEffects of green tea use on the metabolic profile of postmenopausal women: systematic review and meta-analysis
topicGreen Tea Stress Randomized Trial
claimPolyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ).
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicGreen Tea Stress Randomized Trial
claimWhile many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicGreen Tea Stress Randomized Trial
claimControlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicGreen Tea Stress Randomized Trial
claimAMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities