topicGreen Tea Extract Cardiometabolic Meta-Analysis
claim1 Metabolic syndrome (MetS) is a multifactorial disorder characterized by a cluster of metabolic and cardiovascular abnormalities, including central obesity, dyslipidemia, insulin resistance, and hypertension, which collectively increase the risk of suffering from metabolic diseases such as type 2 diabetes and cardiovascular diseases in the long term [].
evidence level4
citationde la Fuente-Muñoz Mario (2026)
sourceEnhanced Effects of Complex Tea Extract and the Postbiotic BPL1 ® HT on Ameliorating the Cardiometabolic Alterations Associated with Metabolic Syndrome in Mice
topicGreen Tea Extract Cardiometabolic Meta-Analysis
claimImpairment at any step, such as decreased IRS phosphorylation or PI3K/Akt activity, leads to defective glucose transport, reduced glycogen synthesis, increased lipolysis, and the development of insulin resistance [].
evidence level4
citationde la Fuente-Muñoz Mario (2026)
sourceEnhanced Effects of Complex Tea Extract and the Postbiotic BPL1 ® HT on Ameliorating the Cardiometabolic Alterations Associated with Metabolic Syndrome in Mice
topicGreen Tea Extract Cardiometabolic Meta-Analysis
claim6 7 8 9 10 11 One of the most important factors contributing to the development of insulin resistance is increased adiposity, and particularly visceral adiposity [], a condition that is present in most patients with MetS [].
evidence level4
citationde la Fuente-Muñoz Mario (2026)
sourceEnhanced Effects of Complex Tea Extract and the Postbiotic BPL1 ® HT on Ameliorating the Cardiometabolic Alterations Associated with Metabolic Syndrome in Mice
topicGreen Tea Extract Cardiometabolic Meta-Analysis
claim2 3 4 5 Central to the pathogenesis of MetS is insulin resistance, a condition characterized by the disruption of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, a critical mediator of insulin’s metabolic actions in key metabolic tissues such as liver, muscle, and adipose tissue [,].
evidence level4
citationde la Fuente-Muñoz Mario (2026)
sourceEnhanced Effects of Complex Tea Extract and the Postbiotic BPL1 ® HT on Ameliorating the Cardiometabolic Alterations Associated with Metabolic Syndrome in Mice
topicGreen Tea Extract Cardiometabolic Meta-Analysis
claimLow-grade chronic inflammation and oxidative stress accompany obesity [,] and are at least partly attributed to gut barrier dysfunction that promotes endotoxemia-associated inflammation [].
evidence level4
citationSasaki Geoffrey Y. (2022)
sourceCatechin Bioavailability Following Consumption of a Green Tea Extract Confection Is Reduced in Obese Persons without Affecting Gut Microbial-Derived Valerolactones
topicGreen Tea Extract Cardiometabolic Meta-Analysis
claimObesity-associated metabolic impairments provoke the development of more serious diseases (e.g., cardiovascular disease, diabetes), and may significantly limit the bioavailability, and hence efficacy, of bioactive food components with antioxidant and anti-inflammatory activities that could mitigate disease progression.
evidence level4
citationSasaki Geoffrey Y. (2022)
sourceCatechin Bioavailability Following Consumption of a Green Tea Extract Confection Is Reduced in Obese Persons without Affecting Gut Microbial-Derived Valerolactones
topicGreen Tea Extract Cardiometabolic Meta-Analysis
claimThe bioavailability of polyphenolic catechins has been studied extensively in healthy persons, with evidence showing that maximum plasma concentrations reach 0.07–1.8 µM within 1–3 h of ingestion and their half-lives range from 2.5 to 5.7 h [].
evidence level4
citationSasaki Geoffrey Y. (2022)
sourceCatechin Bioavailability Following Consumption of a Green Tea Extract Confection Is Reduced in Obese Persons without Affecting Gut Microbial-Derived Valerolactones
topicGreen Tea Extract Cardiometabolic Meta-Analysis
claim1 2 3 4 5 6 Obesity is a major public health issue with over two-thirds of Americans classified as overweight or obese [].
evidence level4
citationSasaki Geoffrey Y. (2022)
sourceCatechin Bioavailability Following Consumption of a Green Tea Extract Confection Is Reduced in Obese Persons without Affecting Gut Microbial-Derived Valerolactones