Structured evidence table for Grape Seed Extract Skin Hydration Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Grape Seed Extract Skin Hydration Randomized Trial | Notably, the concentration of PIC required for certain in vitro activities remains higher than those typically achieved in vivo, and the current evidence base for PIC in human skin is considerably less developed than that for resveratrol. | 3 | Zhang Dian (2026) | Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive |
| Grape Seed Extract Skin Hydration Randomized Trial | We aim to: (1) synthesize the evidence for PIC’s multi-target activity in skin aging and acne; (2) critically evaluate existing in vivo and clinical data to identify key evidence gaps; and (3) propose a phase-gate translational framework that prioritizes standardization, sustainable sourcing, nano-delivery, and clinical validation. | 3 | Zhang Dian (2026) | Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive |
| Grape Seed Extract Skin Hydration Randomized Trial | Figure 3 Table 1 29 A robust body of in vitro and ex vivo evidence delineates PIC’s pleiotropic effects across the interconnected pathways driving skin aging and dysfunction, as summarized inand. | 3 | Zhang Dian (2026) | Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive |
| Grape Seed Extract Skin Hydration Randomized Trial | Passiflora edulis 1 2 Figure 1 3 The global juice processing industry generates substantial quantities of passion fruit () seed waste, an agro-industrial byproduct that is often underutilized or discarded [,] (). | 3 | Zhang Dian (2026) | Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive |
| Grape Seed Extract Skin Hydration Randomized Trial | In regenerative dermatology and cosmetic surgery, stem cell‐based approaches aim to address structural and functional deterioration associated with aging, injury, or cosmetic alteration, promoting cellular mechanisms that contribute to tissue repair, neovascularization, and extracellular matrix synthesis []. | 4 | KarkonShayan Farid (2026) | Stem Cells in Cosmetic Applications: Advancements, Challenges, and Future Directions |
| Grape Seed Extract Skin Hydration Randomized Trial | In addition to direct cell‐based therapies, the concept of stem cell‐derived secretomes is gaining prominence, offering potential cosmetic benefits without the regulatory and safety complexities associated with administering living cells []. | 4 | KarkonShayan Farid (2026) | Stem Cells in Cosmetic Applications: Advancements, Challenges, and Future Directions |
| Grape Seed Extract Skin Hydration Randomized Trial | As a result, plant stem cell extracts produced by this method are now widely used in both daily and professional cosmetic products. | 4 | KarkonShayan Farid (2026) | Stem Cells in Cosmetic Applications: Advancements, Challenges, and Future Directions |
| Grape Seed Extract Skin Hydration Randomized Trial | DNA IL‐6 LACCE Leontopodium alpinum callus culture extract LPS LSCECC Coffea canephora leaf stem cell extract of RSCEs Rosa damascena stem cell–derived exosomes RSCs Rosa damascena stem cells UV UV‐A UV‐B VEGF 1 2 3 4 5 6 Biotechnology has greatly affected the cosmetic field by creating new ways to produce active ingredients that can slow down skin aging []. | 4 | KarkonShayan Farid (2026) | Stem Cells in Cosmetic Applications: Advancements, Challenges, and Future Directions |
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