topicGrape Seed Extract Blood Pressure Randomized Trial
claimSeverity, frequency and duration of migraine attacks, headache daily result (HDR), quality of life, migraine disability, mental health, anthropometric indices, blood pressure, and serum levels of calcitonin gene-related peptide (CGRP), vascular cell adhesion molecules-1, total antioxidant capacity, and malondialdehyde were measured at baseline and end of the trial.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicGrape Seed Extract Blood Pressure Randomized Trial
claimConclusion This study provides evidence supporting the beneficial effects of GSE supplement on the serum levels of CGRP.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicGrape Seed Extract Blood Pressure Randomized Trial
claimBackground The current study was conducted to assess the effect of grape seed extract (GSE) supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in migraine patients.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicGrape Seed Extract Blood Pressure Randomized Trial
claimMaterials and methods In this randomized double-blinded controlled clinical trial, 50 patients with migraine were randomly allocated to receive either 200 mg/day GSE supplement ( n = 25) or placebo ( n = 25) for 8 weeks.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicGrape Seed Extract Blood Pressure Randomized Trial
claimIn addition, there is growing evidence that seed extracts benefit the intestinal microbiota, modulate lipid metabolism, and have antihypertensive activity, reinforcing their nutraceutical applicability [].
evidence level3
citationFernandes Dayane Stéphanie (2026)
sourceFruit Seeds with Functional Applications: From Food Waste to Potential Uses
topicGrape Seed Extract Blood Pressure Randomized Trial
claimThe fruits selected for description in this study are widely consumed by various populations around the world, are used at an industrial scale, and, as a result, generate large-scale seed production, from which oils and bioactive compounds can be extracted for various applications in the cosmetic, pharmaceutical, and food industries.
evidence level3
citationFernandes Dayane Stéphanie (2026)
sourceFruit Seeds with Functional Applications: From Food Waste to Potential Uses
topicGrape Seed Extract Blood Pressure Randomized Trial
claimIt should be noted that the quality of an oil is directly associated with its chemical composition, which depends on agronomic factors, climatic conditions, the variety and state of ripeness, technological factors related to extraction, such as the method and type of equipment used, as well as the conditions of harvesting, storage, and transportation of the product [].
evidence level3
citationFernandes Dayane Stéphanie (2026)
sourceFruit Seeds with Functional Applications: From Food Waste to Potential Uses
topicGrape Seed Extract Blood Pressure Randomized Trial
claim1 2 3 Fruit processing, both on an industrial and domestic scale, results in the generation of solid waste which, when disposed of improperly, can cause considerable economic and environmental impacts [].
evidence level3
citationFernandes Dayane Stéphanie (2026)
sourceFruit Seeds with Functional Applications: From Food Waste to Potential Uses