topicFucoidan Immune Function Randomized Trial
claimFor seaweed sulfated polysaccharides, however, the evidence is not yet strong enough to claim that they are bona fide trained-immunity inducers.
evidence level3
citationLiu Wei (2026)
sourceSeaweed sulfated polysaccharides regulate the gut microbiota-mucosal barrier-innate immunity axis: structural heterogeneity, immunological evidence, and translational prospects
topicFucoidan Immune Function Randomized Trial
claimThe present review is organized around four interconnected levels: the major polysaccharide classes and their structural heterogeneity; their interactions with the gut microbiota and microbial enzyme systems; the innate immune and mucosal barrier pathways involved; and the disease-relevant evidence together with the key translational bottlenecks that remain to be addressed.
evidence level3
citationLiu Wei (2026)
sourceSeaweed sulfated polysaccharides regulate the gut microbiota-mucosal barrier-innate immunity axis: structural heterogeneity, immunological evidence, and translational prospects
topicFucoidan Immune Function Randomized Trial
claimThe evidence was organized along a unified analytical chain, from structural features to microbial metabolism, barrier outcomes, and immune readouts, so that studies differing in source material, processing, and model systems could be compared and key knowledge gaps identified.
evidence level3
citationLiu Wei (2026)
sourceSeaweed sulfated polysaccharides regulate the gut microbiota-mucosal barrier-innate immunity axis: structural heterogeneity, immunological evidence, and translational prospects
topicFucoidan Immune Function Randomized Trial
claim1 5 Seaweed polysaccharides are among the most mature and versatile molecular families in marine natural product research.
evidence level3
citationLiu Wei (2026)
sourceSeaweed sulfated polysaccharides regulate the gut microbiota-mucosal barrier-innate immunity axis: structural heterogeneity, immunological evidence, and translational prospects