Structured evidence table for Folate Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Folate Cognition Randomized Trial | Background : The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study was a 3-year randomized controlled trial to test the effects of the MIND diet on cognitive decline in individuals at risk for Alzheimer's dementia (AD). | 2 | Cornelis MC (2026) | Genetic Variation in Response to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND): A Randomized Controlled Trial. |
| Folate Cognition Randomized Trial | Met / Met (lower enzyme activity) carriers' perceptual speed improved more on the MIND than the control diet, while no difference by diet was observed for Val carriers. | 2 | Cornelis MC (2026) | Genetic Variation in Response to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND): A Randomized Controlled Trial. |
| Folate Cognition Randomized Trial | Here we examine whether genetic differences in (a) AD predisposition and (b) nutrient metabolism modify the effect of MIND on cognitive change. | 2 | Cornelis MC (2026) | Genetic Variation in Response to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND): A Randomized Controlled Trial. |
| Folate Cognition Randomized Trial | This mini-review synthesizes current evidence on dietary and lifestyle interventions for AD prevention and management from randomized controlled trials (RCTs) and observational studies. | 3 | Zhang H (2026) | The role of nutrition and multimodal lifestyle interventions in Alzheimer's prevention and management: a mini-review. |
| Folate Cognition Randomized Trial | Current findings indicate that multidomain approaches, such as the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and the Finnish Geriatric Intervention Study (FINGER) model, which integrate nutrition, physical activity, and cognitive training, consistently demonstrate efficacy in slowing cognitive decline and reducing brain atrophy in at-risk elderly populations. | 3 | Zhang H (2026) | The role of nutrition and multimodal lifestyle interventions in Alzheimer's prevention and management: a mini-review. |
| Folate Cognition Randomized Trial | The evidence for specific nutritional supplements is mixed; however, certain combinations like omega-3 fatty acids paired with carotenoids, B vitamins (folate/B12), and probiotics show promise, particularly for improving memory and reducing inflammation. | 3 | Zhang H (2026) | The role of nutrition and multimodal lifestyle interventions in Alzheimer's prevention and management: a mini-review. |
| Folate Cognition Randomized Trial | Alzheimer's disease (AD) is a progressive and currently incurable neurodegenerative disorder, which is driving a paradigm shift in research focus toward preventive and disease-modifying strategies. | 3 | Zhang H (2026) | The role of nutrition and multimodal lifestyle interventions in Alzheimer's prevention and management: a mini-review. |
Source documents