topicFermented Soy Bone Health Randomized Trial
claimRather than acting independently, these hallmarks interact through complex immunometabolic and stress-response networks, collectively contributing to functional decline and increased susceptibility to chronic diseases.
evidence level3
citationKryczyk-Poprawa Agata (2026)
sourceGut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience
topicFermented Soy Bone Health Randomized Trial
claimEmerging evidence suggests that the gut microbiota and its metabolites influence multiple hallmarks of aging simultaneously, thereby providing a mechanistic link between nutrition, metabolism, immunity, and healthy aging.
evidence level3
citationKryczyk-Poprawa Agata (2026)
sourceGut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience
topicFermented Soy Bone Health Randomized Trial
claim2 3 Increasing evidence suggests that the gut microbiota contributes to several biological processes involved in aging and age-related diseases, although many mechanistic relationships remain incompletely understood [].
evidence level3
citationKryczyk-Poprawa Agata (2026)
sourceGut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience
topicFermented Soy Bone Health Randomized Trial
claim1 Aging is a multifactorial biological process characterized by progressive functional decline accompanied by chronic low-grade inflammation (inflammaging), immune dysregulation, metabolic dysfunction, frailty, sarcopenia, and cognitive impairment [].
evidence level3
citationKryczyk-Poprawa Agata (2026)
sourceGut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience
topicFermented Soy Bone Health Randomized Trial
claim1 2 3 4 5 6 7 8 9 10 Lactiplantibacillus pentosus Lactiplantibacillus plantarum Ageing is a multifactorial biological process characterized by progressive functional decline and increased risk of chronic diseases.
evidence level4
citationWang Luwei (2026)
sourceLactic Acid Bacteria-Fermented Natural Products: Mechanisms and Evidence for Ageing- and Stem-Cell-Related Outcomes
topicFermented Soy Bone Health Randomized Trial
claimFor example, fermentation of the herb Lespedeza cuneata withincreased its flavonoid content about 2.5-fold and significantly improved antioxidant and anti-ageing activity [].
evidence level4
citationWang Luwei (2026)
sourceLactic Acid Bacteria-Fermented Natural Products: Mechanisms and Evidence for Ageing- and Stem-Cell-Related Outcomes
topicFermented Soy Bone Health Randomized Trial
claimWe prioritised studies that identified the fermentation system and reported a biological endpoint; evidence is interpreted here according to whether it arose from human, animal, cellular, or mechanistic work.
evidence level4
citationWang Luwei (2026)
sourceLactic Acid Bacteria-Fermented Natural Products: Mechanisms and Evidence for Ageing- and Stem-Cell-Related Outcomes
topicFermented Soy Bone Health Randomized Trial
claimA central challenge in geroscience is identifying interventions that slow ageing by targeting its key mechanisms, such as oxidative stress, chronic inflammation, and stem cell exhaustion [,,].
evidence level4
citationWang Luwei (2026)
sourceLactic Acid Bacteria-Fermented Natural Products: Mechanisms and Evidence for Ageing- and Stem-Cell-Related Outcomes