topicErgothioneine Skin Hydration Randomized Trial
claimNevertheless, the procedure carries a potential risk of post‐inflammatory hyperpigmentation (PIH) [], especially among individuals with Fitzpatrick skin type IV, which is prevalent in the Chinese population [].
evidence level2
citationHe Yixuan (2026)
sourceEfficacy of 1064‐Nm Picosecond Nd: YAG Laser in Treating Facial Photoaging and Improving Skin Barrier Enhanced by a Multi‐Beneficial Composition Formulation: A Blinded Randomized Clinical Trial Study
topicErgothioneine Skin Hydration Randomized Trial
claim1 At the end of the study, the efficacy rates for all symptoms were found to be higher on the test sides than on the control sides (Figure ).
evidence level2
citationHe Yixuan (2026)
sourceEfficacy of 1064‐Nm Picosecond Nd: YAG Laser in Treating Facial Photoaging and Improving Skin Barrier Enhanced by a Multi‐Beneficial Composition Formulation: A Blinded Randomized Clinical Trial Study
topicErgothioneine Skin Hydration Randomized Trial
claimp p p p Because of postoperative edema, SCH values were significantly increased on both sides at T3d compared with baseline (both < 0.001), indicating a transiently compromised skin barrier, and returned to baseline levels by T8d.
evidence level2
citationHe Yixuan (2026)
sourceEfficacy of 1064‐Nm Picosecond Nd: YAG Laser in Treating Facial Photoaging and Improving Skin Barrier Enhanced by a Multi‐Beneficial Composition Formulation: A Blinded Randomized Clinical Trial Study
topicErgothioneine Skin Hydration Randomized Trial
claimEI HA MAPK MI NF‐κB NO Nrf2 PIH SCH SE SSRI TEWL TNF‐α 1 2 3 4 5 In recent years, skin photoaging has received increasing attention.
evidence level2
citationHe Yixuan (2026)
sourceEfficacy of 1064‐Nm Picosecond Nd: YAG Laser in Treating Facial Photoaging and Improving Skin Barrier Enhanced by a Multi‐Beneficial Composition Formulation: A Blinded Randomized Clinical Trial Study
topicErgothioneine Skin Hydration Randomized Trial
claimIn addition, global life expectancy has increased from 60 to 70 years for both males and females over the last 20 years (B).
evidence level4
citationSun Yidan (2026)
sourceAn integrated anti-aging framework targeting NAD + homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
topicErgothioneine Skin Hydration Randomized Trial
claimAging is closely associated with a high incidence of multiple chronic diseases, including congestive heart failure, myocardial infarction, dementia, stroke, most cancers, diabetes and metabolic disorders, renal dysfunction, chronic lung disease, osteoporosis, arthritis, and vision loss [].
evidence level4
citationSun Yidan (2026)
sourceAn integrated anti-aging framework targeting NAD + homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
topicErgothioneine Skin Hydration Randomized Trial
claimParticular attention was given to compounds with substantial experimental evidence demonstrating their ability to modulate mitochondrial metabolism, mitochondrial biogenesis and quality control, or mitochondrial redox stability.
evidence level4
citationSun Yidan (2026)
sourceAn integrated anti-aging framework targeting NAD + homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT
topicErgothioneine Skin Hydration Randomized Trial
claim1 4 5 1 2 A: Global Population Aged 60 and Over and Related Percentage; B: Global Life Expectancy.
evidence level4
citationSun Yidan (2026)
sourceAn integrated anti-aging framework targeting NAD + homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT