evidence table

Electrolytes Cramps Prevention Randomized Trial Evidence Table

Structured evidence table for Electrolytes Cramps Prevention Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Electrolytes Cramps Prevention Randomized TrialTemporomandibular disorders (TMDs) are among the most common causes of chronic orofacial pain, with myalgia of the masticatory muscles being a major.Patients frequently present with persistent aching pain, muscle tenderness, and restricted jaw function, all of which significantly impair quality of life.While existing treatments are mainly symptomatic,emerging evidence suggests a role for electrolyte modulation.1Patil Shankargouda (2026)The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
Electrolytes Cramps Prevention Randomized TrialNotably, a recent randomized controlled trial demonstrated that local magnesium sulphate injection into the masseter muscle significantly reduced pain intensity and improved function in TMD myalgia, providing a direct clinical link between electrolyte biology and orofacial pain.This observation highlights the potential for broader exploration of electrolyte-based interventions in TMD.1Patil Shankargouda (2026)The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
Electrolytes Cramps Prevention Randomized TrialMuscle cramps – whether idiopathic nocturnal, pregnancy-associated, or exercise-induced – arise from abnormal neuromuscular excitability,impaired ion-channel regulation,and nociceptor sensitization.These same processes are also implicated in TMD myalgia,suggesting that insights from cramp interventions may inform novel strategies for managing orofacial muscle pain.1Patil Shankargouda (2026)The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
Electrolytes Cramps Prevention Randomized TrialNCT02913664 The Exercise and Intensive Vascular Risk Reduction in Preventing Dementia (rrAD study) was a multicenter randomized, controlled trial to determine the effects of moderate to vigorous aerobic exercise training and intensive pharmacological treatment of cardiovascular risk factors on dementia prevention in older adults ().2Hall Tristyn (2025)Adverse Events in a Multicenter Randomized Controlled Trial for Dementia Prevention (rrAD study)
Electrolytes Cramps Prevention Randomized TrialOur objective is to determine whether the trial interventions were associated with higher reports of AEs in older adults aged 60 to 85 who had hypertension, family history of dementia, and/or subjective memory complaints.2Hall Tristyn (2025)Adverse Events in a Multicenter Randomized Controlled Trial for Dementia Prevention (rrAD study)
topicElectrolytes Cramps Prevention Randomized Trial
claimTemporomandibular disorders (TMDs) are among the most common causes of chronic orofacial pain, with myalgia of the masticatory muscles being a major.Patients frequently present with persistent aching pain, muscle tenderness, and restricted jaw function, all of which significantly impair quality of life.While existing treatments are mainly symptomatic,emerging evidence suggests a role for electrolyte modulation.
evidence level1
citationPatil Shankargouda (2026)
sourceThe Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
topicElectrolytes Cramps Prevention Randomized Trial
claimNotably, a recent randomized controlled trial demonstrated that local magnesium sulphate injection into the masseter muscle significantly reduced pain intensity and improved function in TMD myalgia, providing a direct clinical link between electrolyte biology and orofacial pain.This observation highlights the potential for broader exploration of electrolyte-based interventions in TMD.
evidence level1
citationPatil Shankargouda (2026)
sourceThe Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
topicElectrolytes Cramps Prevention Randomized Trial
claimMuscle cramps – whether idiopathic nocturnal, pregnancy-associated, or exercise-induced – arise from abnormal neuromuscular excitability,impaired ion-channel regulation,and nociceptor sensitization.These same processes are also implicated in TMD myalgia,suggesting that insights from cramp interventions may inform novel strategies for managing orofacial muscle pain.
evidence level1
citationPatil Shankargouda (2026)
sourceThe Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
topicElectrolytes Cramps Prevention Randomized Trial
claimNCT02913664 The Exercise and Intensive Vascular Risk Reduction in Preventing Dementia (rrAD study) was a multicenter randomized, controlled trial to determine the effects of moderate to vigorous aerobic exercise training and intensive pharmacological treatment of cardiovascular risk factors on dementia prevention in older adults ().
evidence level2
citationHall Tristyn (2025)
sourceAdverse Events in a Multicenter Randomized Controlled Trial for Dementia Prevention (rrAD study)
topicElectrolytes Cramps Prevention Randomized Trial
claimOur objective is to determine whether the trial interventions were associated with higher reports of AEs in older adults aged 60 to 85 who had hypertension, family history of dementia, and/or subjective memory complaints.
evidence level2
citationHall Tristyn (2025)
sourceAdverse Events in a Multicenter Randomized Controlled Trial for Dementia Prevention (rrAD study)

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Source documents

  1. The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
  2. Adverse Events in a Multicenter Randomized Controlled Trial for Dementia Prevention (rrAD study)