topicEaa Muscle Recovery Randomized Trial
claimResults The eccentric protocol elicited responses consistent with EIMD, including increased soreness ( p p p = 0.018).
evidence level2
citationVasenina E (2026)
sourceEffects of essential amino acid supplementation on musculotendinous recovery following eccentric plantar flexor exercise: a randomized controlled trial.
topicEaa Muscle Recovery Randomized Trial
claimCalf muscle thickness increased following exercise in both groups; however, swelling returned to baseline by 72 hours in the EAA group but remained elevated in placebo (Condition × Time, p p = 0.005) but was not influenced by supplementation.
evidence level2
citationVasenina E (2026)
sourceEffects of essential amino acid supplementation on musculotendinous recovery following eccentric plantar flexor exercise: a randomized controlled trial.
topicEaa Muscle Recovery Randomized Trial
claimConclusions EAA supplementation modestly reduced soreness and was associated with faster recovery of muscle swelling but did not influence tendon morphology within 72 hours.
evidence level2
citationVasenina E (2026)
sourceEffects of essential amino acid supplementation on musculotendinous recovery following eccentric plantar flexor exercise: a randomized controlled trial.
topicEaa Muscle Recovery Randomized Trial
claimBackground Exercise-induced muscle damage (EIMD) resulting from eccentric contractions leads to transient impairments in muscle function.
evidence level2
citationVasenina E (2026)
sourceEffects of essential amino acid supplementation on musculotendinous recovery following eccentric plantar flexor exercise: a randomized controlled trial.
topicEaa Muscle Recovery Randomized Trial
claimA major contributing factor is the combined increase in protein breakdown and reduced protein intake, which is likely a response to inflammation and related changes in the immune system, including altered (either increased or reduced) cytokine levels [,].
evidence level4
citationDeutz Nicolaas E.P. (2026)
sourceThe metabolic effects of post-sepsis feeding of meals with only essential amino acids
topicEaa Muscle Recovery Randomized Trial
claimThis caution is necessary because the gastrointestinal tract and systemic metabolism must readapt after the period of reduced food intake and gut-barrier dysfunction typical of sepsis [].
evidence level4
citationDeutz Nicolaas E.P. (2026)
sourceThe metabolic effects of post-sepsis feeding of meals with only essential amino acids
topicEaa Muscle Recovery Randomized Trial
claimHowever, we have shown that during sepsis, the NEAA arginine becomes conditionally essential due to a reduced conversion of citrulline to arginine (arginine production) [,].
evidence level4
citationDeutz Nicolaas E.P. (2026)
sourceThe metabolic effects of post-sepsis feeding of meals with only essential amino acids
topicEaa Muscle Recovery Randomized Trial
claim1 2 3 4 5 6 Sepsis remains a global health concern, with focus increasingly shifting from acute survival to the protracted recovery phase [,].
evidence level4
citationDeutz Nicolaas E.P. (2026)
sourceThe metabolic effects of post-sepsis feeding of meals with only essential amino acids