Structured evidence table for Creatine Older Adults Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Creatine Older Adults Cognition Randomized Trial | These changes contribute to increased sarcopenia risk during and after the menopausal transition, with implications for physical function, frailty, and long-term musculoskeletal health []. | 1 | Naddafha Siavash (2026) | Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis |
| Creatine Older Adults Cognition Randomized Trial | In addition, creatine may exert direct anabolic or anticatabolic effects on muscle cells and influence bone via increased muscle pulling forces or direct cell signaling in osteoblasts []. | 1 | Naddafha Siavash (2026) | Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis |
| Creatine Older Adults Cognition Randomized Trial | For example, a 12-week RCT reported that creatine (5 g/day) with RT significantly increased muscle strength and fat-free mass in women aged ~65 years []. | 1 | Naddafha Siavash (2026) | Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis |
| Creatine Older Adults Cognition Randomized Trial | 1 2 3 4 5 6 6 Muscle and bone loss accelerate during the postmenopausal years due to aging and estrogen deficiency. | 1 | Naddafha Siavash (2026) | Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis |
| Creatine Older Adults Cognition Randomized Trial | 1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults (). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| Creatine Older Adults Cognition Randomized Trial | 1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence (). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| Creatine Older Adults Cognition Randomized Trial | Low circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| Creatine Older Adults Cognition Randomized Trial | In this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials. | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
Source documents