topicCreatine Cognitive Performance Sleep Deprivation Randomized Trial
claimThere is growing evidence indicating that creatine influences neuronal excitability and neurotransmission.
evidence level4
citationGordji-Nejad Ali (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance
topicCreatine Cognitive Performance Sleep Deprivation Randomized Trial
claimIn all the above cases, a cellular stress state appears to be a decisive condition for an increased uptake.
evidence level4
citationGordji-Nejad Ali (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance
topicCreatine Cognitive Performance Sleep Deprivation Randomized Trial
claimIf both factors are responsible for increased creatine absorption, the question arises of whether a customary dose is sufficient to achieve the same effect, as this minimizes side effects and improves the safety of consumers.
evidence level4
citationGordji-Nejad Ali (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance
topicCreatine Cognitive Performance Sleep Deprivation Randomized Trial
claim1 2 3 4 2 5 3 6 4 7 8 9 10 11 12 13 8 14 15 16 17 2 18 19 20 21 22 23 A 1 2 1A Creatine is a supplement primarily used by the sports community to improve physical performance.
evidence level4
citationGordji-Nejad Ali (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance
topicCreatine Cognitive Performance Sleep Deprivation Randomized Trial
claim1 2 4 – 5 8 – 1 31 9 14 – 10 15 , The modern lifestyle and work pressure favor sleep deprivation (SD), leading to more accidents, reduced performance, and chronic diseases.
evidence level4
citationGordji-Nejad Ali (2024)
sourceSingle dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation
topicCreatine Cognitive Performance Sleep Deprivation Randomized Trial
claimA study by, starting with early measurements after 3 days of Cr supplementation, found no significant change in cerebral tCr level in the brain.
evidence level4
citationGordji-Nejad Ali (2024)
sourceSingle dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation
topicCreatine Cognitive Performance Sleep Deprivation Randomized Trial
claimOther studies have found increased creatine levels when supplemented in a modified form or mixed with additional components.
evidence level4
citationGordji-Nejad Ali (2024)
sourceSingle dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation
topicCreatine Cognitive Performance Sleep Deprivation Randomized Trial
claimTo diminish these negative consequences, psychoactive substances such as caffeine gained immense popularity in recent decades.
evidence level4
citationGordji-Nejad Ali (2024)
sourceSingle dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation