topicCreatine Cognitive Fatigue Randomized Trial
claimThe importance of the timing of Cr administration is based on the assumption that exercise-induced physiological changes, such as increased hyperemia and altered transport dynamics, may optimize tissue absorption and storage [].
evidence level2
citationBen Maaoui Khouloud (2026)
sourceAcute Creatine Ingestion Before Resistance Training Enhances Strength Performance More than Ingestion During or After Training: A Randomized Crossover Pilot Trial
topicCreatine Cognitive Fatigue Randomized Trial
claimYet, evidence supporting specific timing strategies is restricted to a few chronic studies with conflicting findings [,,].
evidence level2
citationBen Maaoui Khouloud (2026)
sourceAcute Creatine Ingestion Before Resistance Training Enhances Strength Performance More than Ingestion During or After Training: A Randomized Crossover Pilot Trial
topicCreatine Cognitive Fatigue Randomized Trial
claim[] found distinct differences between pre- and post-exercise ingestion regarding strength and hypertrophy over a 32-week intervention in older adults.
evidence level2
citationBen Maaoui Khouloud (2026)
sourceAcute Creatine Ingestion Before Resistance Training Enhances Strength Performance More than Ingestion During or After Training: A Randomized Crossover Pilot Trial
topicCreatine Cognitive Fatigue Randomized Trial
claim1 2 3 3 4 5 6 7 Creatine (Cr) (α-methyl guanidino-acetic acid) is primarily synthesized endogenously in the kidneys and liver [,].
evidence level2
citationBen Maaoui Khouloud (2026)
sourceAcute Creatine Ingestion Before Resistance Training Enhances Strength Performance More than Ingestion During or After Training: A Randomized Crossover Pilot Trial
topicCreatine Cognitive Fatigue Randomized Trial
claimThe present study investigates whether supplementation of a lower dose is associated with cognitive effects during sleep deprivation, focusing exclusively on cognitive performance outcomes.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Cognitive Fatigue Randomized Trial
claimConclusions: Our results show that a dose of 0.2 g/kg creatine is associated with a reduced deterioration in cognitive performance during sleep deprivation.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Cognitive Fatigue Randomized Trial
claimBackground/Objectives: Creatine is a supplement that, beyond its physiological effects, has been shown to have positive effects on cognitive abilities.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Cognitive Fatigue Randomized Trial
claimIn our previous study, we showed that a single dose of 0.35 g/kg creatine induces changes in brain metabolism during sleep deprivation and reduces deterioration in cognitive performance.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.