Structured evidence table for Creatine Cognition Sleep Deprivation Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Creatine Cognition Sleep Deprivation Randomized Trial | There is some evidence that creatine supplementation improves outcome measures in those with muscular dystrophy but not other neurological diseases or conditions such as Parkinson’s disease or amyotrophic lateral sclerosis. | 3 | Candow Darren G. (2023) | “Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function |
| Creatine Cognition Sleep Deprivation Randomized Trial | The vast majority of evidence-based research has focused on the efficacy of creatine monohydrate and exercise (primarily resistance-type training) for improving measures of muscle/lean mass, muscle performance (including strength, endurance, and power), and recovery from sport or exercise in young healthy male adults []. | 3 | Candow Darren G. (2023) | “Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function |
| Creatine Cognition Sleep Deprivation Randomized Trial | There is evidence that high-dose creatine supplementation (e.g., ≥ 20 g/day) can yield increases in creatine levels in the brain over periods of several weeks and perhaps overcome a reduction in endogenous creatine synthesis inside the CNS [], but the replenishment of the brain creatine pool is still slow and limited []. | 3 | Candow Darren G. (2023) | “Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function |
| Creatine Cognition Sleep Deprivation Randomized Trial | Creatine supplementation can improve cognition and memory, especially in older adults or during times of metabolic stress (i.e., sleep deprivation). | 3 | Candow Darren G. (2023) | “Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function |
| Creatine Cognition Sleep Deprivation Randomized Trial | Creatine, a nitrogenous organic compound derived from reactions involving the amino acids arginine, glycine, and methionine, is important for resynthesizing ATP, particularly during times of increased metabolic demand (e.g., sleep deprivation, mental health conditions, or neurological diseases) [,,]. | 3 | Forbes Scott C. (2022) | Effects of Creatine Supplementation on Brain Function and Health |
| Creatine Cognition Sleep Deprivation Randomized Trial | [] demonstrated increased muscle creatine levels following oral creatine monohydrate supplementation. | 3 | Forbes Scott C. (2022) | Effects of Creatine Supplementation on Brain Function and Health |
| Creatine Cognition Sleep Deprivation Randomized Trial | Intramuscular creatine levels can be further increased when creatine monohydrate ingestion is combined with exercise [,], insulin [], carbohydrate [], carbohydrate and protein [], or lipoic acid []. | 3 | Forbes Scott C. (2022) | Effects of Creatine Supplementation on Brain Function and Health |
| Creatine Cognition Sleep Deprivation Randomized Trial | 1 2 3 4 5 6 6 7 The brain is a highly energetic complex organ, consuming approximately 20% of total resting energy despite accounting for only about 2% of total body mass []. | 3 | Forbes Scott C. (2022) | Effects of Creatine Supplementation on Brain Function and Health |
Source documents