supplement evidence

Cordyceps Fatigue Randomized Trial Evidence Table

Structured evidence table for Cordyceps Fatigue Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Cordyceps Fatigue Randomized TrialEmerging empirical evidence indicates that a simultaneous approach targeting mitochondrial function, one-carbon metabolism, and catecholaminergic pathways may yield a more efficacious strategy than isolated interventions ().3Xu Chunhong (2026)Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
Cordyceps Fatigue Randomized TrialThe dysregulation of methylation pathways has been associated with the onset of metabolic syndrome, cognitive decline, and muscular dysfunction ().3Xu Chunhong (2026)Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
Cordyceps Fatigue Randomized TrialThe process of aging, along with metabolic disorders, is often correlated with compromised dopaminergic signaling, which contributes to diminished physical performance and increased levels of fatigue.3Xu Chunhong (2026)Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
Cordyceps Fatigue Randomized Trial1 2 3 4 5 6 7 8 9 Athletic performance represents a multifaceted phenotype influenced by the interplay of mitochondrial bioenergetics, epigenetic modulation, and neurotransmitter signaling ().3Xu Chunhong (2026)Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
Cordyceps Fatigue Randomized TrialCordyceps extracts are generally well tolerated and have not been associated with serum aminotransferase elevations during therapy or with cases of clinically apparent acute liver injury.4Hoofnagle JH (2026)Cordyceps
Cordyceps Fatigue Randomized TrialCordyceps is the common name for several insect-parasitizing fungi, particularly Ophiocordyceps sinensis (formerly Cordyceps sinensis) and Cordyceps militaris.4Hoofnagle JH (2026)Cordyceps
Cordyceps Fatigue Randomized TrialExtracts of these species of have been used in traditional Chinese medicine to treat multiple conditions including fatigue, aging, sexual dysfunction, and diabetes.4Hoofnagle JH (2026)Cordyceps
topicCordyceps Fatigue Randomized Trial
claimEmerging empirical evidence indicates that a simultaneous approach targeting mitochondrial function, one-carbon metabolism, and catecholaminergic pathways may yield a more efficacious strategy than isolated interventions ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicCordyceps Fatigue Randomized Trial
claimThe dysregulation of methylation pathways has been associated with the onset of metabolic syndrome, cognitive decline, and muscular dysfunction ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicCordyceps Fatigue Randomized Trial
claimThe process of aging, along with metabolic disorders, is often correlated with compromised dopaminergic signaling, which contributes to diminished physical performance and increased levels of fatigue.
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicCordyceps Fatigue Randomized Trial
claim1 2 3 4 5 6 7 8 9 Athletic performance represents a multifaceted phenotype influenced by the interplay of mitochondrial bioenergetics, epigenetic modulation, and neurotransmitter signaling ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicCordyceps Fatigue Randomized Trial
claimCordyceps extracts are generally well tolerated and have not been associated with serum aminotransferase elevations during therapy or with cases of clinically apparent acute liver injury.
evidence level4
citationHoofnagle JH (2026)
sourceCordyceps
topicCordyceps Fatigue Randomized Trial
claimCordyceps is the common name for several insect-parasitizing fungi, particularly Ophiocordyceps sinensis (formerly Cordyceps sinensis) and Cordyceps militaris.
evidence level4
citationHoofnagle JH (2026)
sourceCordyceps
topicCordyceps Fatigue Randomized Trial
claimExtracts of these species of have been used in traditional Chinese medicine to treat multiple conditions including fatigue, aging, sexual dysfunction, and diabetes.
evidence level4
citationHoofnagle JH (2026)
sourceCordyceps

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Source documents

  1. Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
  2. Cordyceps