evidence table

Cocoa Supplementation Blood Flow Randomized Trial Evidence Table

Structured evidence table for Cocoa Supplementation Blood Flow Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Cocoa Supplementation Blood Flow Randomized TrialThe meta-analysis showed a significant effect of cocoa supplementation on triacylglycerol levels (-0.21 mmol/L, 95% CI: -0.40, -0.02; p = 0.0333), and subgroup analysis suggested that cholesterol levels were reduced with cocoa supplementation in patients with dyslipidemia and diabetes.1Gomes Chagas A (2026)The effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysis.
Cocoa Supplementation Blood Flow Randomized TrialOur study suggests that cocoa intake has limited evidence of benefit, mainly for triglycerides, furthermore, effects and that the duration, type, and clinical status of patients were important determinants for favorable effects on biomarkers related to metabolic syndrome.1Gomes Chagas A (2026)The effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysis.
Cocoa Supplementation Blood Flow Randomized TrialCocoa supplementation has been shown to improve parameters related to metabolic syndrome, although results have been contradictory.1Gomes Chagas A (2026)The effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysis.
Cocoa Supplementation Blood Flow Randomized TrialWe conducted a systematic review and meta-analysis to examine the effect of cocoa products on lipid and glycemic profiles, blood pressure levels, and anthropometric measurements in individuals with metabolic syndrome and related diseases.1Gomes Chagas A (2026)The effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysis.
Cocoa Supplementation Blood Flow Randomized TrialPolyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ).3Akif Adnan (2026)Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
Cocoa Supplementation Blood Flow Randomized TrialWhile many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error.3Akif Adnan (2026)Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
Cocoa Supplementation Blood Flow Randomized TrialControlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints.3Akif Adnan (2026)Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
Cocoa Supplementation Blood Flow Randomized TrialAMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide.3Akif Adnan (2026)Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicCocoa Supplementation Blood Flow Randomized Trial
claimThe meta-analysis showed a significant effect of cocoa supplementation on triacylglycerol levels (-0.21 mmol/L, 95% CI: -0.40, -0.02; p = 0.0333), and subgroup analysis suggested that cholesterol levels were reduced with cocoa supplementation in patients with dyslipidemia and diabetes.
evidence level1
citationGomes Chagas A (2026)
sourceThe effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysis.
topicCocoa Supplementation Blood Flow Randomized Trial
claimOur study suggests that cocoa intake has limited evidence of benefit, mainly for triglycerides, furthermore, effects and that the duration, type, and clinical status of patients were important determinants for favorable effects on biomarkers related to metabolic syndrome.
evidence level1
citationGomes Chagas A (2026)
sourceThe effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysis.
topicCocoa Supplementation Blood Flow Randomized Trial
claimCocoa supplementation has been shown to improve parameters related to metabolic syndrome, although results have been contradictory.
evidence level1
citationGomes Chagas A (2026)
sourceThe effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysis.
topicCocoa Supplementation Blood Flow Randomized Trial
claimWe conducted a systematic review and meta-analysis to examine the effect of cocoa products on lipid and glycemic profiles, blood pressure levels, and anthropometric measurements in individuals with metabolic syndrome and related diseases.
evidence level1
citationGomes Chagas A (2026)
sourceThe effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysis.
topicCocoa Supplementation Blood Flow Randomized Trial
claimPolyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ).
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicCocoa Supplementation Blood Flow Randomized Trial
claimWhile many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicCocoa Supplementation Blood Flow Randomized Trial
claimControlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicCocoa Supplementation Blood Flow Randomized Trial
claimAMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities

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Source documents

  1. The effects of cocoa products in individuals with metabolic syndrome and related diseases: a systematic review and meta-analysis.
  2. Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities