Structured evidence table for Cocoa Flavanols Memory Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Cocoa Flavanols Memory Randomized Trial | Polyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ). | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Flavanols Memory Randomized Trial | While many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Flavanols Memory Randomized Trial | Controlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Flavanols Memory Randomized Trial | AMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Flavanols Memory Randomized Trial | Managing risk factors through healthy eating habits and regular exercise is crucial for CVD prevention. | 3 | Lee Yu Geon (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review |
| Cocoa Flavanols Memory Randomized Trial | Unsaturated fatty acids found in olive oil and nuts can help prevent CVDs by regulating cholesterol metabolism. | 3 | Lee Yu Geon (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review |
| Cocoa Flavanols Memory Randomized Trial | Additionally, improving the diet by reducing salt intake and limiting processed foods can also help mitigate risk factors for CVD []. | 3 | Lee Yu Geon (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review |
| Cocoa Flavanols Memory Randomized Trial | 1 2 2 3 According to the World Health Organization, cardiovascular diseases (CVDs), including coronary artery heart disease, cerebrovascular diseases, rheumatic heart disease, and other related conditions, are the leading cause of death worldwide, with an estimated 17.9 million deaths annually []. | 3 | Lee Yu Geon (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review |
Source documents