topicCocoa Flavanols Cognitive Performance Randomized Trial
claimPhysical performance measures predict fall risk.Weak grip strength, slow walking speed, and other measures of poor physical performance have been associated with recurrent falls, hospitalization, and fractures.Given the personal and economic burden, safe and effective interventions are needed to prevent falls and maintain good physical function in older adults.
evidence level2
citationChou Sharon H (2026)
sourceEffects of cocoa extract supplementation on physical performance measures: results from the randomized controlled COcoa Supplement and Multivitamin Outcomes study
topicCocoa Flavanols Cognitive Performance Randomized Trial
claimp p Over 2 yr, urinary gVLM increased from mean (±SE) of 9.5 ± 1.0 to 21.1 ± 1.8 μmol/L in the cocoa extract group.
evidence level2
citationChou Sharon H (2026)
sourceEffects of cocoa extract supplementation on physical performance measures: results from the randomized controlled COcoa Supplement and Multivitamin Outcomes study
topicCocoa Flavanols Cognitive Performance Randomized Trial
claimThere were minimal declines in walking speeds (≤−0.04 m/s) and increased time for the completion of chair stands (<0.8 s) across all treatment groups.
evidence level2
citationChou Sharon H (2026)
sourceEffects of cocoa extract supplementation on physical performance measures: results from the randomized controlled COcoa Supplement and Multivitamin Outcomes study
topicCocoa Flavanols Cognitive Performance Randomized Trial
claimIn the United States, there are more than 3 million emergency department visits per year for falls in adults 65 yr and older, and falls are the leading cause of death due to injury in this age group.In total, medical costs for falls exceed $80 billion/yr in the United States.
evidence level2
citationChou Sharon H (2026)
sourceEffects of cocoa extract supplementation on physical performance measures: results from the randomized controlled COcoa Supplement and Multivitamin Outcomes study
topicCocoa Flavanols Cognitive Performance Randomized Trial
claim1 2 3 3 3 4 5 6 The characteristics of dementia syndrome are cognitive dysfunction, including memory loss, reduced executive functions, language impairment, and affected performance in daily life activities [].
evidence level4
citationSbai Oualid (2026)
sourceThe Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review
topicCocoa Flavanols Cognitive Performance Randomized Trial
claimNotably, about 70% of older people are living in low–middle income countries [], representing a significant economic weight associated with medical costs for health systems [].
evidence level4
citationSbai Oualid (2026)
sourceThe Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review
topicCocoa Flavanols Cognitive Performance Randomized Trial
claimIn addition, it is necessary to unveil the risk factors promoting dementia in order to develop preventive strategies.
evidence level4
citationSbai Oualid (2026)
sourceThe Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review
topicCocoa Flavanols Cognitive Performance Randomized Trial
claimDementia affects approximately 55 million individuals worldwide, and its prevalence is expected to rise up to 131.5 million by 2050, representing a major global health challenge [,].
evidence level4
citationSbai Oualid (2026)
sourceThe Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review