evidence table
Cocoa Flavanol Memory Randomized Trial Evidence Table
Structured evidence table for Cocoa Flavanol Memory Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Cocoa Flavanol Memory Randomized Trial | 6 2,7–9 10 11 12 13 Although amyloid-beta and tau hypotheses have been the primary hypotheses in the underlying pathogenesis of AD, emerging evidence suggests that amyloidegenesis can be exacerbated by oxidative stress, leading to AD development and progression []. | 3 | Zainuddin Muhammad-Safuan (2026) | Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives |
| Cocoa Flavanol Memory Randomized Trial | Growing evidence suggests that oxidative stress and impairment of innate antioxidative defence may precede the pathological features of AD and clinical manifestations [,]. | 3 | Zainuddin Muhammad-Safuan (2026) | Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives |
| Cocoa Flavanol Memory Randomized Trial | Therefore, this review aims to highlight evidence of oxidative biomarkers across different specimens, including post-mortem brain and biofluids in AD patients compared to the healthy population. | 3 | Zainuddin Muhammad-Safuan (2026) | Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives |
| Cocoa Flavanol Memory Randomized Trial | 1 1 2 1 3 4 5 Alzheimer's disease (AD) is the most prominent age-related neurodegenerative disease in the world []. | 3 | Zainuddin Muhammad-Safuan (2026) | Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives |
| Cocoa Flavanol Memory Randomized Trial | 1 2 3 3 3 4 5 6 The characteristics of dementia syndrome are cognitive dysfunction, including memory loss, reduced executive functions, language impairment, and affected performance in daily life activities []. | 4 | Sbai Oualid (2026) | The Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review |
| Cocoa Flavanol Memory Randomized Trial | Notably, about 70% of older people are living in low–middle income countries [], representing a significant economic weight associated with medical costs for health systems []. | 4 | Sbai Oualid (2026) | The Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review |
| Cocoa Flavanol Memory Randomized Trial | In addition, it is necessary to unveil the risk factors promoting dementia in order to develop preventive strategies. | 4 | Sbai Oualid (2026) | The Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review |
| Cocoa Flavanol Memory Randomized Trial | Dementia affects approximately 55 million individuals worldwide, and its prevalence is expected to rise up to 131.5 million by 2050, representing a major global health challenge [,]. | 4 | Sbai Oualid (2026) | The Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review |
Source documents