evidence table

Cocoa Flavanol Cognitive Performance Randomized Trial Evidence Table

Name: Cocoa Flavanol Cognitive Performance Randomized Trial Evidence Table
Creator: Migaku
License: https://creativecommons.org/licenses/by/4.0/

Structured evidence table for Cocoa Flavanol Cognitive Performance Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topic	claim	evidence level	citation	source
Cocoa Flavanol Cognitive Performance Randomized Trial	6 2,7–9 10 11 12 13 Although amyloid-beta and tau hypotheses have been the primary hypotheses in the underlying pathogenesis of AD, emerging evidence suggests that amyloidegenesis can be exacerbated by oxidative stress, leading to AD development and progression [].	3	Zainuddin Muhammad-Safuan (2026)	Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives
Cocoa Flavanol Cognitive Performance Randomized Trial	Growing evidence suggests that oxidative stress and impairment of innate antioxidative defence may precede the pathological features of AD and clinical manifestations [,].	3	Zainuddin Muhammad-Safuan (2026)	Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives
Cocoa Flavanol Cognitive Performance Randomized Trial	Therefore, this review aims to highlight evidence of oxidative biomarkers across different specimens, including post-mortem brain and biofluids in AD patients compared to the healthy population.	3	Zainuddin Muhammad-Safuan (2026)	Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives
Cocoa Flavanol Cognitive Performance Randomized Trial	1 1 2 1 3 4 5 Alzheimer's disease (AD) is the most prominent age-related neurodegenerative disease in the world [].	3	Zainuddin Muhammad-Safuan (2026)	Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives
Cocoa Flavanol Cognitive Performance Randomized Trial	The number of individuals affected by dementia and cognitive decline is progressively increasing, becoming a serious global health challenge.	4	Sbai O (2026)	The Role of Polyphenols on Cognitive Function and Dementia Through Gut-Microbiota-Brain Axis Modulation: A Narrative Review.
Cocoa Flavanol Cognitive Performance Randomized Trial	Several investigations underline the role of nutrition and dietary habits as a preventive strategy.	4	Sbai O (2026)	The Role of Polyphenols on Cognitive Function and Dementia Through Gut-Microbiota-Brain Axis Modulation: A Narrative Review.