topicCocoa Flavanol Blood Pressure Randomized Trial
claimAmong the different forms of the disease, type 2 diabetes mellitus (T2D) accounts for approximately 90–95% of all cases and is strongly associated with insulin resistance, excess adiposity, physical inactivity, and dietary patterns characterized by high consumption of energy-dense, highly processed foods [,].
evidence level3
citationTornero-Aguilera Jose Francisco (2026)
sourceCocoa-Based Plant Matrices in Glucose Metabolism: Bioactive Compounds and Redox Signaling
topicCocoa Flavanol Blood Pressure Randomized Trial
claim6 7 8 Over the past decades, the prevalence of diabetes has increased markedly worldwide, reaching levels of major public health concern.
evidence level3
citationTornero-Aguilera Jose Francisco (2026)
sourceCocoa-Based Plant Matrices in Glucose Metabolism: Bioactive Compounds and Redox Signaling
topicCocoa Flavanol Blood Pressure Randomized Trial
claimThe disease imposes a substantial economic burden on healthcare systems, reduces quality of life, and is associated with a marked increase in mortality risk.
evidence level3
citationTornero-Aguilera Jose Francisco (2026)
sourceCocoa-Based Plant Matrices in Glucose Metabolism: Bioactive Compounds and Redox Signaling
topicCocoa Flavanol Blood Pressure Randomized Trial
claim1 2 3 4 5 Diabetes mellitus comprises a complex and heterogeneous group of metabolic disorders characterized by chronic hyperglycemia resulting from alterations in insulin secretion, insulin action, or a combination of both processes.
evidence level3
citationTornero-Aguilera Jose Francisco (2026)
sourceCocoa-Based Plant Matrices in Glucose Metabolism: Bioactive Compounds and Redox Signaling
topicCocoa Flavanol Blood Pressure Randomized Trial
claimMetS is a multifactorial condition, with its primary indicators including obesity, hypertension, dyslipidemia, insulin resistance, and hyperglycemia; i.e., a patient who possesses at least 3 of the following parameters is designated with MetS: glucose intolerance, increased levels of triglycerides, augmented waist circumference, low levels of high-density lipoprotein cholesterol (HDL-c), and hypertension [,,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCocoa Flavanol Blood Pressure Randomized Trial
claimIt is possible to develop a close relationship with MetS, metabolic dysfunction-associated steatotic liver disease (MASLD), and CVD [,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCocoa Flavanol Blood Pressure Randomized Trial
claimMASLD is strongly associated with various conditions, including MetS, and is characterized by the persistence of a chronic inflammatory state detrimental to the organism [,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCocoa Flavanol Blood Pressure Randomized Trial
claim1 2 3 4 5 6 7 8 9 10 11 12 13 14 Metabolic disorders are increasing sharply due to severe modifications in lifestyle [,,,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors