Structured evidence table for Cocoa-Flavanol-Anxiety-Randomized-Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Cocoa-Flavanol-Anxiety-Randomized-Trial | Polyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ). | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa-Flavanol-Anxiety-Randomized-Trial | While many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa-Flavanol-Anxiety-Randomized-Trial | Controlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa-Flavanol-Anxiety-Randomized-Trial | AMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa-Flavanol-Anxiety-Randomized-Trial | 1 2 3 3 3 4 5 6 The characteristics of dementia syndrome are cognitive dysfunction, including memory loss, reduced executive functions, language impairment, and affected performance in daily life activities []. | 4 | Sbai Oualid (2026) | The Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review |
| Cocoa-Flavanol-Anxiety-Randomized-Trial | Notably, about 70% of older people are living in low–middle income countries [], representing a significant economic weight associated with medical costs for health systems []. | 4 | Sbai Oualid (2026) | The Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review |
| Cocoa-Flavanol-Anxiety-Randomized-Trial | In addition, it is necessary to unveil the risk factors promoting dementia in order to develop preventive strategies. | 4 | Sbai Oualid (2026) | The Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review |
| Cocoa-Flavanol-Anxiety-Randomized-Trial | Dementia affects approximately 55 million individuals worldwide, and its prevalence is expected to rise up to 131.5 million by 2050, representing a major global health challenge [,]. | 4 | Sbai Oualid (2026) | The Role of Polyphenols on Cognitive Function and Dementia Through Gut–Microbiota–Brain Axis Modulation: A Narrative Review |
Source documents