evidence table
Cocoa Cognition Randomized Trial Evidence Table
Structured evidence table for Cocoa Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Cocoa Cognition Randomized Trial | Although with a lesser degree of evidence than established dementia risk factors such as low education, visual impairment, diabetes, hypertension or social isolation, evidence is accumulating on the relationship between dietary factors and cognitive functioning []. | 2 | Ros Emilio (2026) | Are avocados good for the brain? Most likely yes, in spite of their lack of effect on cognitive performance in a well-conducted 6-month randomized controlled trial |
| Cocoa Cognition Randomized Trial | Cohort studies suggest that consumption of healthy foods and adherence to plant-based dietary patterns, such as the Mediterranean diet, are associated with reduced risk of cognitive disorders [,,]. | 2 | Ros Emilio (2026) | Are avocados good for the brain? Most likely yes, in spite of their lack of effect on cognitive performance in a well-conducted 6-month randomized controlled trial |
| Cocoa Cognition Randomized Trial | Mediterranean-type dietary patterns are reputed as both heart-healthy and environmentally sustainable []; additionally, evidence from prospective studies suggest a favorable association with cognitive decline, but no clear link with all-cause dementia or Alzheimer’s disease, the most frequent cause of dementia [,,]. | 2 | Ros Emilio (2026) | Are avocados good for the brain? Most likely yes, in spite of their lack of effect on cognitive performance in a well-conducted 6-month randomized controlled trial |
| Cocoa Cognition Randomized Trial | 1 [2] [3] [4] 5 2 3 6 As population ages, cognitive decline and dementia are becoming leading causes of disability worldwide. | 2 | Ros Emilio (2026) | Are avocados good for the brain? Most likely yes, in spite of their lack of effect on cognitive performance in a well-conducted 6-month randomized controlled trial |
| Cocoa Cognition Randomized Trial | Polyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ). | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Cognition Randomized Trial | While many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Cognition Randomized Trial | Controlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Cognition Randomized Trial | AMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
Source documents
- Are avocados good for the brain? Most likely yes, in spite of their lack of effect on cognitive performance in a well-conducted 6-month randomized controlled trial
- Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities