topicCocoa Blood Pressure Randomized Trial
claimMetS is a multifactorial condition, with its primary indicators including obesity, hypertension, dyslipidemia, insulin resistance, and hyperglycemia; i.e., a patient who possesses at least 3 of the following parameters is designated with MetS: glucose intolerance, increased levels of triglycerides, augmented waist circumference, low levels of high-density lipoprotein cholesterol (HDL-c), and hypertension [,,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCocoa Blood Pressure Randomized Trial
claimIt is possible to develop a close relationship with MetS, metabolic dysfunction-associated steatotic liver disease (MASLD), and CVD [,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCocoa Blood Pressure Randomized Trial
claimMASLD is strongly associated with various conditions, including MetS, and is characterized by the persistence of a chronic inflammatory state detrimental to the organism [,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCocoa Blood Pressure Randomized Trial
claim1 2 3 4 5 6 7 8 9 10 11 12 13 14 Metabolic disorders are increasing sharply due to severe modifications in lifestyle [,,,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCocoa Blood Pressure Randomized Trial
claimRecent randomized trials and longitudinal studies report modest but reproducible benefits on cognitive domains and vascular/endothelial function with berry/grape extracts, matcha/green tea, and high-polyphenol extra-virgin olive oil; effects appear stronger in older adults or those with metabolic risk.
evidence level4
citationAkif A (2026)
sourceDietary Polyphenols in Non-Communicable Chronic Diseases: Neuro-Enteric Mechanisms, Multi-Omics Biomarkers and Translational Opportunities.
topicCocoa Blood Pressure Randomized Trial
claimComplementary evidence in irritable bowel syndrome (IBS)-a prototypical gut-brain disorder-suggests polyphenol-based combinations (often with probiotics/fiber) can improve quality of life and inflammatory markers, supporting enteric-central crosstalk.
evidence level4
citationAkif A (2026)
sourceDietary Polyphenols in Non-Communicable Chronic Diseases: Neuro-Enteric Mechanisms, Multi-Omics Biomarkers and Translational Opportunities.
topicCocoa Blood Pressure Randomized Trial
claimPolyphenols from plant foods (tea, cocoa, berries, grapes, and extra-virgin olive oil) modulate oxidative stress, inflammation, vascular function, and the gut microbiome-axes central to non-communicable chronic diseases (NCCDs) that involve the brain and enteric nervous system (ENS).
evidence level4
citationAkif A (2026)
sourceDietary Polyphenols in Non-Communicable Chronic Diseases: Neuro-Enteric Mechanisms, Multi-Omics Biomarkers and Translational Opportunities.