Citrulline Blood Pressure Randomized Trial Evidence Table

Structured evidence table for Citrulline Blood Pressure Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Citrulline Blood Pressure Randomized TrialThe primary objective of this systematic review and meta-analysis is to investigate whether L-citrulline supplementation can counteract the adverse effects of cold environments on individual blood pressure (BP), providing scientific evidence for the clinical development and application of L-citrulline as a cardiovascular protective nutritional supplement.1Luo P (2026)Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Citrulline Blood Pressure Randomized TrialThe Cochrane Risk of Bias tool and JADAD scoring scale were used to assess risk of bias and literature quality of the included randomized controlled trials (RCTs).1Luo P (2026)Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Citrulline Blood Pressure Randomized TrialResults indicate that L-citrulline intake significantly reduced cold-induced SBP (-9.28 mmHg [95% CI: -10.66 to -7.90], p p = 0.01).1Luo P (2026)Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Citrulline Blood Pressure Randomized TrialA comprehensive search was conducted across four electronic databases: PubMed, Cochrane Library, Embase, and Web of Science.1Luo P (2026)Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Citrulline Blood Pressure Randomized TrialBackground Postmenopausal women are at increased risk of developing cardiovascular, muscular, and metabolic dysfunction due to hormonal changes associated with aging.1Bahari H (2026)Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.
Citrulline Blood Pressure Randomized TrialConclusion Citrulline supplementation may offer benefits for blood pressure regulation (up to 9 mmHg SBP reduction in some studies) in hypertensive postmenopausal women, but evidence for arterial stiffness, endothelial function, and metabolic outcomes remains inconsistent.1Bahari H (2026)Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.
Citrulline Blood Pressure Randomized TrialCitrulline, a non-essential amino acid and precursor to nitric oxide, has gained interest as a potential dietary supplement for improving vascular health, muscle function, and metabolic parameters in this population.1Bahari H (2026)Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.

Source documents

  1. Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
  2. Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.