topicChromium Body Composition Randomized Trial
claimInsulin sensitivity improved significantly, with a 28% greater improvement in the active group than in the placebo group (adjusted geometric mean ratio 1.28; 95% confidence interval 1.14 to 1.44).
evidence level2
citationXenos K (2026)
sourceEffects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial.
topicChromium Body Composition Randomized Trial
claimConclusions The fixed-dose combination improved BIA-derived body-composition measures and OGTT-derived insulin sensitivity over 12 weeks compared with placebo.
evidence level2
citationXenos K (2026)
sourceEffects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial.
topicChromium Body Composition Randomized Trial
claimObjectives To evaluate the efficacy of a fixed-dose combination of berberine, white mulberry leaf extract, and chromium picolinate on body weight, body composition, and insulin sensitivity in Greek adults with obesity.
evidence level2
citationXenos K (2026)
sourceEffects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial.
topicChromium Body Composition Randomized Trial
claimResearch methodology/design This was a 12-week, randomized, double-blind, placebo-controlled trial.
evidence level2
citationXenos K (2026)
sourceEffects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in Adults with Obesity: A Randomized Controlled Trial.
topicChromium Body Composition Randomized Trial
claimIn patients with PMDD, lower γ-aminobutyric acid (GABAA) receptor δ-subunit expression and higher serotonin binding to the serotonin transporter are found in the luteal phase compared with controls, correlated with altered emotional generation through heightened amygdala activation and worse depressive symptoms, respectively [,].
evidence level4
citationSmith Marleigh (2026)
sourceSelf-Reported Changes in Premenstrual and Menstrual Symptoms among Females Taking a Novel Multinutrient Supplement: A Pilot Study
topicChromium Body Composition Randomized Trial
claimPMS is found to involve differences in neurotransmitter functioning, inflammation, and oxidative stress, which may contribute to its severity [,,].
evidence level4
citationSmith Marleigh (2026)
sourceSelf-Reported Changes in Premenstrual and Menstrual Symptoms among Females Taking a Novel Multinutrient Supplement: A Pilot Study
topicChromium Body Composition Randomized Trial
claimSevere menstrual pain is associated with 4-fold higher prostaglandin levels on the first day of menstruation compared with controls [].
evidence level4
citationSmith Marleigh (2026)
sourceSelf-Reported Changes in Premenstrual and Menstrual Symptoms among Females Taking a Novel Multinutrient Supplement: A Pilot Study
topicChromium Body Composition Randomized Trial
claim1 2 3 4 5 6 4 7 Menstrual cycle symptoms affect ≤90% of menstruating individuals [].
evidence level4
citationSmith Marleigh (2026)
sourceSelf-Reported Changes in Premenstrual and Menstrual Symptoms among Females Taking a Novel Multinutrient Supplement: A Pilot Study