evidence table
Choline Cognition Randomized Trial Evidence Table
Structured evidence table for Choline Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Choline Cognition Randomized Trial | 1 The first 1000 days of life—from conception and pregnancy through the first 2 years—represent a period often described as a “window of opportunity” to promote better developmental outcomes, but it can also be considered a “window of susceptibility,” during which adverse epigenetic influences, an increased risk of disease development and nutritional deficiency may occur []. | 3 | Sollena Laura Maria (2026) | DHA: Nutritional Programming During the First 1000 Days of Life |
| Choline Cognition Randomized Trial | Eligible studies included randomized controlled trials, follow-up studies, systematic reviews and meta-analyses, and observational studies reporting clinical, developmental, or biochemical outcomes associated with DHA exposure. | 3 | Sollena Laura Maria (2026) | DHA: Nutritional Programming During the First 1000 Days of Life |
| Choline Cognition Randomized Trial | Level of evidence (LOE) was qualitatively assigned according to GRADE, used as a conceptual framework rather than a formal systematic grading approach. | 3 | Sollena Laura Maria (2026) | DHA: Nutritional Programming During the First 1000 Days of Life |
| Choline Cognition Randomized Trial | 2 The essential role of nutrition on brain development during the first 1000 days is widely recognized []. | 3 | Sollena Laura Maria (2026) | DHA: Nutritional Programming During the First 1000 Days of Life |
| Choline Cognition Randomized Trial | Evidence from clinical and preclinical studies confirms that maternal choline intake is critical for neurogenesis, cognition, and visual system development, and that higher choline availability buffers the fetal brain against environmental and psychosocial stressors. | 4 | Paules EM (2025) | Future Directions in Choline: From Neurodevelopment to Cardiometabolic Health. |
| Choline Cognition Randomized Trial | Although choline was established as an essential nutrient over three decades ago, critical questions remain about how choline regulates brain, liver, and cardiometabolic health across the lifespan. | 4 | Paules EM (2025) | Future Directions in Choline: From Neurodevelopment to Cardiometabolic Health. |
| Choline Cognition Randomized Trial | This Perspective summarizes emerging insights presented at the Future Directions in Choline Symposium: A Tribute to Steven H. | 4 | Paules EM (2025) | Future Directions in Choline: From Neurodevelopment to Cardiometabolic Health. |
Source documents