Structured evidence table for Chicory Root Fiber Blood Glucose Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Chicory Root Fiber Blood Glucose Randomized Trial | Clinically, chRG-I was well-tolerated and slightly improved stool consistency compared to placebo. | 4 | Kerezoudi EN (2026) | Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults. |
| Chicory Root Fiber Blood Glucose Randomized Trial | In an intestinal barrier challenge model, chRG-I fermentates (a pool of metabolites including SCFA and fragments of chRG-I) protected barrier integrity, modulated the cytokine milieu away from a predominantly pro-inflammatory response, as characterized by increased IL4 and IL22 and reduced IL9, IL17A, and IL21. | 4 | Kerezoudi EN (2026) | Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults. |
| Chicory Root Fiber Blood Glucose Randomized Trial | Conclusion: Supplementation with a low dose of chRG-I is well-tolerated, beneficially modulates the gut microbiome - which can protect the intestinal barrier, and subtly enhances systemic immune readiness, suggesting that chRG-I may have benefits as a functional food ingredient. | 4 | Kerezoudi EN (2026) | Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults. |
| Chicory Root Fiber Blood Glucose Randomized Trial | Background: Pectic rhamnogalacturonan-I (RG-I) is a dietary fiber that modulates the gut-immune axis. | 4 | Kerezoudi EN (2026) | Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults. |
| Chicory Root Fiber Blood Glucose Randomized Trial | Interestingly, we previously found that short-term (3 weeks), daily intake of 30 g/day of dried chicory root fibers in individuals at risk of T2D rapidly modulated the gut microbiota by increasing relative levels ofspp. | 4 | Omary Lina (2025) | Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity |
| Chicory Root Fiber Blood Glucose Randomized Trial | Interestingly, we show a pivotal role of the intrinsic chicory root fibers in modulating microbial butyrate production pathways and fecal SCFA concentrations, as well as whole-body insulin sensitivity, insulin-mediated non-oxidative glucose disposal, fasting circulating glucose, and triglyceride (TG) concentrations with trends toward an increased peripheral insulin sensitivity and reduced liver fat accumulation. | 4 | Omary Lina (2025) | Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity |
| Chicory Root Fiber Blood Glucose Randomized Trial | Additionally, we noticed a shift in adipocyte cell size toward smaller adipocytes, indicating an improved adipocyte function independent of any weight changes. | 4 | Omary Lina (2025) | Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity |
| Chicory Root Fiber Blood Glucose Randomized Trial | by 3-fold that could form a butyrogenic trophic chain.This was accompanied by higher levels of fecal SCFAs, including a 20% increase in butyrate.Additionally, using fecalbatch fermentations, we confirmed high production levels of SCFAs from the intrinsic fiber product, notably at a late stage during the fermentation, coinciding with the presence of pectin-degrading and butyrate-producing bacteria. | 4 | Omary Lina (2025) | Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity |
Source documents