evidence table

Chicory Root Blood Glucose Randomized Trial Evidence Table

Structured evidence table for Chicory Root Blood Glucose Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Chicory Root Blood Glucose Randomized Trial1 2 [,] 3 6 [–] Hemoglobinopathies are among the most prevalent monogenic disorders worldwide, with an estimated 1–5% of the global population carrying genetic mutations associated with thalassemia.2Ansari Damavandi Shahla (2025)Evaluating the effect of chicory on serum ferritin levels in transfusion-dependent Β-thalassemia patients: a randomized clinical trial
Chicory Root Blood Glucose Randomized Trialβ-thalassemia, characterized by reduced or absent synthesis of β-globin chains, is predominantly found in regions such as the Mediterranean, the Middle East, and India.2Ansari Damavandi Shahla (2025)Evaluating the effect of chicory on serum ferritin levels in transfusion-dependent Β-thalassemia patients: a randomized clinical trial
Chicory Root Blood Glucose Randomized TrialFurthermore, individuals with thalassemia demonstrate increased intestinal iron absorption, and patients with more severe forms of the disease may experience iron deposition in the reticuloendothelial system as a consequence of repeated transfusions.2Ansari Damavandi Shahla (2025)Evaluating the effect of chicory on serum ferritin levels in transfusion-dependent Β-thalassemia patients: a randomized clinical trial
Chicory Root Blood Glucose Randomized TrialClinically, chRG-I was well-tolerated and slightly improved stool consistency compared to placebo.4Kerezoudi EN (2026)Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.
Chicory Root Blood Glucose Randomized TrialIn an intestinal barrier challenge model, chRG-I fermentates (a pool of metabolites including SCFA and fragments of chRG-I) protected barrier integrity, modulated the cytokine milieu away from a predominantly pro-inflammatory response, as characterized by increased IL4 and IL22 and reduced IL9, IL17A, and IL21.4Kerezoudi EN (2026)Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.
Chicory Root Blood Glucose Randomized TrialConclusion: Supplementation with a low dose of chRG-I is well-tolerated, beneficially modulates the gut microbiome - which can protect the intestinal barrier, and subtly enhances systemic immune readiness, suggesting that chRG-I may have benefits as a functional food ingredient.4Kerezoudi EN (2026)Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.
Chicory Root Blood Glucose Randomized TrialBackground: Pectic rhamnogalacturonan-I (RG-I) is a dietary fiber that modulates the gut-immune axis.4Kerezoudi EN (2026)Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.
topicChicory Root Blood Glucose Randomized Trial
claim1 2 [,] 3 6 [–] Hemoglobinopathies are among the most prevalent monogenic disorders worldwide, with an estimated 1–5% of the global population carrying genetic mutations associated with thalassemia.
evidence level2
citationAnsari Damavandi Shahla (2025)
sourceEvaluating the effect of chicory on serum ferritin levels in transfusion-dependent Β-thalassemia patients: a randomized clinical trial
topicChicory Root Blood Glucose Randomized Trial
claimβ-thalassemia, characterized by reduced or absent synthesis of β-globin chains, is predominantly found in regions such as the Mediterranean, the Middle East, and India.
evidence level2
citationAnsari Damavandi Shahla (2025)
sourceEvaluating the effect of chicory on serum ferritin levels in transfusion-dependent Β-thalassemia patients: a randomized clinical trial
topicChicory Root Blood Glucose Randomized Trial
claimFurthermore, individuals with thalassemia demonstrate increased intestinal iron absorption, and patients with more severe forms of the disease may experience iron deposition in the reticuloendothelial system as a consequence of repeated transfusions.
evidence level2
citationAnsari Damavandi Shahla (2025)
sourceEvaluating the effect of chicory on serum ferritin levels in transfusion-dependent Β-thalassemia patients: a randomized clinical trial
topicChicory Root Blood Glucose Randomized Trial
claimClinically, chRG-I was well-tolerated and slightly improved stool consistency compared to placebo.
evidence level4
citationKerezoudi EN (2026)
sourceDietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.
topicChicory Root Blood Glucose Randomized Trial
claimIn an intestinal barrier challenge model, chRG-I fermentates (a pool of metabolites including SCFA and fragments of chRG-I) protected barrier integrity, modulated the cytokine milieu away from a predominantly pro-inflammatory response, as characterized by increased IL4 and IL22 and reduced IL9, IL17A, and IL21.
evidence level4
citationKerezoudi EN (2026)
sourceDietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.
topicChicory Root Blood Glucose Randomized Trial
claimConclusion: Supplementation with a low dose of chRG-I is well-tolerated, beneficially modulates the gut microbiome - which can protect the intestinal barrier, and subtly enhances systemic immune readiness, suggesting that chRG-I may have benefits as a functional food ingredient.
evidence level4
citationKerezoudi EN (2026)
sourceDietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.
topicChicory Root Blood Glucose Randomized Trial
claimBackground: Pectic rhamnogalacturonan-I (RG-I) is a dietary fiber that modulates the gut-immune axis.
evidence level4
citationKerezoudi EN (2026)
sourceDietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.

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Source documents

  1. Evaluating the effect of chicory on serum ferritin levels in transfusion-dependent Β-thalassemia patients: a randomized clinical trial
  2. Dietary chicory rhamnogalacturonan-I modulates gut microbiota and immune responses in healthy adults.