Structured evidence table for Ceramides Skin Hydration Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Ceramides Skin Hydration Randomized Trial | The incidence of adverse events was comparable between groups, and no adverse drug reactions were found. | 2 | Kubo S (2026) | Effects of Sphingomyelin on Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. |
| Ceramides Skin Hydration Randomized Trial | Background Sphingomyelin (Sph) is a bioactive phospholipid, and its ingestion is suggested to improve skin conditions. | 2 | Kubo S (2026) | Effects of Sphingomyelin on Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. |
| Ceramides Skin Hydration Randomized Trial | The participants were healthy adult women aged 30-59 years recruited in Japan, who ingested a tablet containing dairy-derived Sph (23.6 mg/day) or a placebo tablet for 12 weeks. | 2 | Kubo S (2026) | Effects of Sphingomyelin on Skin Conditions in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. |
| Ceramides Skin Hydration Randomized Trial | Clinical evidence supports the efficacy of ceramide-dominant formulations in improving hydration and reducing transepidermal water loss (TEWL), with studies reporting TEWL reductions of approximately 10% and hydration improvement lasting up to 72 hours. | 4 | De A (2026) | Oryza Ceramax in Dermatologic Care: A Multi-pathway Approach to Skin Hydration and Barrier Repair. |
| Ceramides Skin Hydration Randomized Trial | Its formulation characteristics are consistent with evidence-based principles for skin barrier protection and hydration maintenance. | 4 | De A (2026) | Oryza Ceramax in Dermatologic Care: A Multi-pathway Approach to Skin Hydration and Barrier Repair. |
| Ceramides Skin Hydration Randomized Trial | Environmental stressors, including climate change, pollution, and lifestyle factors, can disrupt the skin barrier, leading to dryness and exacerbating conditions such as atopic dermatitis (AD), acne, and psoriasis. | 4 | De A (2026) | Oryza Ceramax in Dermatologic Care: A Multi-pathway Approach to Skin Hydration and Barrier Repair. |
| Ceramides Skin Hydration Randomized Trial | Effective barrier repair requires maintaining hydration and lipid balance, particularly the ceramide-cholesterol-fatty acid ratio of 3:1:1, which is recommended by dermatological societies for optimal skin restoration. | 4 | De A (2026) | Oryza Ceramax in Dermatologic Care: A Multi-pathway Approach to Skin Hydration and Barrier Repair. |
Source documents