Structured evidence table for Carob Fiber Cholesterol Randomized Trial, generated from 3 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Carob Fiber Cholesterol Randomized Trial | Emphasis is placed on its rich content of polyphenols, flavonoids, dietary fiber, proteins, and essential minerals, which have been associated with antioxidant, antidiabetic, antidiarrheal, antimicrobial, and cardiometabolic-related activities. | 4 | Ben Hsouna A (2026) | Ceratonia siliqua: Phytochemistry, Bioactivity, and Its Emerging Role as a Sustainable Food and Industrial Resource. |
| Carob Fiber Cholesterol Randomized Trial | siliqua), commonly known as the carob tree, is an evergreen species of the Fabaceae family native to the Mediterranean basin and increasingly cultivated worldwide. | 4 | Ben Hsouna A (2026) | Ceratonia siliqua: Phytochemistry, Bioactivity, and Its Emerging Role as a Sustainable Food and Industrial Resource. |
| Carob Fiber Cholesterol Randomized Trial | Traditionally valued as animal feed and a natural sweetener, it has recently gained recognition as a multifunctional plant resource with nutritional, pharmaceutical, and industrial relevance. | 4 | Ben Hsouna A (2026) | Ceratonia siliqua: Phytochemistry, Bioactivity, and Its Emerging Role as a Sustainable Food and Industrial Resource. |
| Carob Fiber Cholesterol Randomized Trial | This narrative review critically evaluates current evidence on the role of D-pinitol in glucose homeostasis and energy balance, integrating data from chemical characterization studies, mechanistic research, preclinical models, and human clinical trials assessing purified D-pinitol and D-pinitol-rich preparations, particularly from carob-derived sources. | 4 | Torres-Oteros D (2026) | Carob (<i>Ceratonia siliqua</i> L.) in Glucose Homeostasis and Energy Balance: The Role of D-Pinitol. |
| Carob Fiber Cholesterol Randomized Trial | Available evidence suggests that D-pinitol may enhance insulin signaling efficiency, primarily through PI3K/Akt-dependent pathways, modulate hepatic metabolic flexibility, and influence endocrine balance without acting as a classical hypoglycemic agent. | 4 | Torres-Oteros D (2026) | Carob (<i>Ceratonia siliqua</i> L.) in Glucose Homeostasis and Energy Balance: The Role of D-Pinitol. |
| Carob Fiber Cholesterol Randomized Trial | The global rise in obesity and metabolic disorders has intensified interest in dietary bioactives capable of improving glycemic control and metabolic health. | 4 | Torres-Oteros D (2026) | Carob (<i>Ceratonia siliqua</i> L.) in Glucose Homeostasis and Energy Balance: The Role of D-Pinitol. |
| Carob Fiber Cholesterol Randomized Trial | Inositols, particularly D-pinitol, have emerged as insulin-sensitizing cyclitols with potential metabolic relevance. | 4 | Torres-Oteros D (2026) | Carob (<i>Ceratonia siliqua</i> L.) in Glucose Homeostasis and Energy Balance: The Role of D-Pinitol. |
| Carob Fiber Cholesterol Randomized Trial | The use of thiazides, beta-blockers, corticosteroids, cyclosporine, protease inhibitors, steroid hormones, and atypical antipsychotics has also been shown to be associated with lipid level disturbances. | 4 | Nemet Marko (2022) | Lipid-Lowering Effects of Carob Extracts ( Ceratonia siliqua ): Proposed Mechanisms and Clinical Importance |
| Carob Fiber Cholesterol Randomized Trial | The carob tree (), found all around the world, originates from the Mediterranean region. | 4 | Nemet Marko (2022) | Lipid-Lowering Effects of Carob Extracts ( Ceratonia siliqua ): Proposed Mechanisms and Clinical Importance |
| Carob Fiber Cholesterol Randomized Trial | Tannins, gallic acid, catechins, myricetin, quercetin, flavonoids, and their derivatives are the polyphenolic compounds that are found in carob () while the insoluble fiber consists of cellulose and hemicellulose (). | 4 | Nemet Marko (2022) | Lipid-Lowering Effects of Carob Extracts ( Ceratonia siliqua ): Proposed Mechanisms and Clinical Importance |
| Carob Fiber Cholesterol Randomized Trial | Hachem and Mooradian, 2006 Yanai and Yoshida, 2021 Falk, 2006 Pirillo et al., 2021 Nies et al., 2006 Grundy et al., 2019 Sirtori, 2014 Okopien et al., 2018 The global prevalence of dyslipidemia [elevated plasma levels of total cholesterol, LDL-cholesterol, triglycerides (TAG), and lower plasma levels of HDL-cholesterol] is constantly on the rise. | 4 | Nemet Marko (2022) | Lipid-Lowering Effects of Carob Extracts ( Ceratonia siliqua ): Proposed Mechanisms and Clinical Importance |
Source documents