Structured evidence table for Carnosine Fatigue Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Carnosine Fatigue Randomized Trial | The Cochrane Risk of Bias (ROB) 2.0 tool was used to assess the ROB in randomized controlled trials (RCTs). | 1 | Hsiao YF (2026) | The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis. |
| Carnosine Fatigue Randomized Trial | Additionally, meta-analysis results showed that L-carnosine combined with anserine or antioxidant supplementation significantly improved the MMSE score compared to placebo (pooled net change = 0.62; 95% CI 0.23, 1.01), with small statistical heterogeneity ( I 2 = 21.3%). | 1 | Hsiao YF (2026) | The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis. |
| Carnosine Fatigue Randomized Trial | Conclusions: A low strength of evidence suggests that L-carnosine supplement combined with anserine or antioxidants can slow cognitive function decline among healthy elderly or patients with probable Alzheimer's Disease or mild neurocognitive disorder. | 1 | Hsiao YF (2026) | The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis. |
| Carnosine Fatigue Randomized Trial | Introduction: Previous research has shown that L-carnosine (β-alanyl-L-histidine) can reduce cognitive decline and improve mental health outcomes, but an updated systematic review of the effects of carnosine alone or in combination with other supplemental nutrients or bioactive compounds on these interconnected outcomes is lacking. | 1 | Hsiao YF (2026) | The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis. |
| Carnosine Fatigue Randomized Trial | 1 1 2 3 4 5 6 7 8 9–14 Carnosine (β-alanine-L-histidine) and its biochemically modified derivatives comprise a family of histidyl-containing dipeptides found in abundance in highly metabolic tissues (skeletal muscle, heart, brain) of all species []. | 2 | O'Toole Timothy E. (2026) | Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial |
| Carnosine Fatigue Randomized Trial | In part due to such diverse roles, both clinical and animal studies have found that increasing carnosine levels can protect from ischemic injury [,], neurodegenerative disease [], toxic outcomes of air pollution exposure [], and promote wound healing [], glucose handling [,] and cognitive function []. | 2 | O'Toole Timothy E. (2026) | Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial |
| Carnosine Fatigue Randomized Trial | In our analysis of physical performance we observed that carnosine improved muscular and cardiovascular endurance in select age groups. | 2 | O'Toole Timothy E. (2026) | Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial |
| Carnosine Fatigue Randomized Trial | Due to its unique chemical structure, carnosine participates in a range of biochemical reactions that support its role in maintaining tissue homeostasis. | 2 | O'Toole Timothy E. (2026) | Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial |
Source documents