Structured evidence table for Carnosine Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Carnosine Cognition Randomized Trial | The Cochrane Risk of Bias (ROB) 2.0 tool was used to assess the ROB in randomized controlled trials (RCTs). | 1 | Hsiao YF (2026) | The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis. |
| Carnosine Cognition Randomized Trial | Additionally, meta-analysis results showed that L-carnosine combined with anserine or antioxidant supplementation significantly improved the MMSE score compared to placebo (pooled net change = 0.62; 95% CI 0.23, 1.01), with small statistical heterogeneity ( I 2 = 21.3%). | 1 | Hsiao YF (2026) | The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis. |
| Carnosine Cognition Randomized Trial | Conclusions: A low strength of evidence suggests that L-carnosine supplement combined with anserine or antioxidants can slow cognitive function decline among healthy elderly or patients with probable Alzheimer's Disease or mild neurocognitive disorder. | 1 | Hsiao YF (2026) | The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis. |
| Carnosine Cognition Randomized Trial | Introduction: Previous research has shown that L-carnosine (β-alanyl-L-histidine) can reduce cognitive decline and improve mental health outcomes, but an updated systematic review of the effects of carnosine alone or in combination with other supplemental nutrients or bioactive compounds on these interconnected outcomes is lacking. | 1 | Hsiao YF (2026) | The Effects of Carnosine on Cognitive Function and Mental Health-A Systematic Review and Meta-Analysis. |
| Carnosine Cognition Randomized Trial | Background Carnosine (β-alanine-L-histidine) is an endogenous dipeptide found in abundance in highly metabolic tissues such as skeletal muscle and the brain, where it is thought to play a role in intracellular buffering, and thereby, promote anaerobic glycolysis. | 2 | O'Toole TE (2026) | Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial. |
| Carnosine Cognition Randomized Trial | Due to its perceived ability to support muscle energetics, carnosine, and its precursor, β-alanine, have found widespread use as performance-enhancing supplements. | 2 | O'Toole TE (2026) | Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial. |
Source documents