evidence table
Calcium Bone Health Randomized Trial Evidence Table
Structured evidence table for Calcium Bone Health Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Calcium Bone Health Randomized Trial | Supported by this biological plausibility and by observational studies demonstrating a robust inverse association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of fractures and falls, the medical community has witnessed a global surge in vitamin D screening and empiric supplementation over the past two decades []. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Calcium Bone Health Randomized Trial | Furthermore, updated systematic reviews and meta-analyses published in 2025 have reinforced the conclusion that vitamin D supplementation does not reduce fall risk among community-dwelling older adults, with some analyses even suggesting potential harm at higher doses [-]. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Calcium Bone Health Randomized Trial | Most notably, the 2024 Endocrine Society Clinical Practice Guideline now recommends against empiric vitamin D supplementation in healthy adults younger than 75 years, signaling a decisive transition from universal screening toward a more targeted, risk-based approach []. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Calcium Bone Health Randomized Trial | 1 2 3 Vitamin D, often termed the ‘sunshine hormone,’ has been a cornerstone of musculoskeletal preventive medicine for decades. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Calcium Bone Health Randomized Trial | Despite its many benefits, weight loss is also associated with loss of bone and lean mass [,]. | 4 | He Jiahuan Helen (2026) | Weight loss lifestyle intervention and bone health hormonal markers in type 2 diabetes: analysis from look AHEAD study |
| Calcium Bone Health Randomized Trial | 4-8 5-8 9 Look AHEAD (Action for Health in Diabetes) was a multicenter randomized controlled trial aimed at assessing whether long-term weight loss-targeted intensive lifestyle intervention (ILI), involving dietary restriction and increased physical activity, could lower cardiovascular morbidity and mortality in people with overweight/obesity and T2D. | 4 | He Jiahuan Helen (2026) | Weight loss lifestyle intervention and bone health hormonal markers in type 2 diabetes: analysis from look AHEAD study |
| Calcium Bone Health Randomized Trial | In addition to its cardiometabolic benefits, the intervention was found to be associated with bone loss []. | 4 | He Jiahuan Helen (2026) | Weight loss lifestyle intervention and bone health hormonal markers in type 2 diabetes: analysis from look AHEAD study |
| Calcium Bone Health Randomized Trial | 1 2 3 Weight loss through healthy lifestyle interventions has been linked to a wide range of metabolic benefits in people with type 2 diabetes (T2D) []. | 4 | He Jiahuan Helen (2026) | Weight loss lifestyle intervention and bone health hormonal markers in type 2 diabetes: analysis from look AHEAD study |
Source documents