topicCacao Flavanol Exercise Performance Randomized Trial
claimIt includes increased interferons, tumor necrosis factor, bradykinin, serine proteases, and soluble thrombomodulin, and altered clot lysis times [,,,,], all of which contribute to microvascular and thrombotic disease [,].
evidence level2
citationMunguía Levy (2026)
sourceEffects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial
topicCacao Flavanol Exercise Performance Randomized Trial
claimA myriad of causes can trigger fatigue, but its development has been strongly associated with post-viral phases of infection.
evidence level2
citationMunguía Levy (2026)
sourceEffects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial
topicCacao Flavanol Exercise Performance Randomized Trial
claimLong COVID-associated fatigue has been causally linked to sustained inflammation and to endothelial and mitochondrial dysfunction.
evidence level2
citationMunguía Levy (2026)
sourceEffects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial
topicCacao Flavanol Exercise Performance Randomized Trial
claim1 2 3 4 5 6 7 8 Coronavirus disease 2019 (COVID-19) is caused by the acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
evidence level2
citationMunguía Levy (2026)
sourceEffects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial
topicCacao Flavanol Exercise Performance Randomized Trial
claimMetS is a multifactorial condition, with its primary indicators including obesity, hypertension, dyslipidemia, insulin resistance, and hyperglycemia; i.e., a patient who possesses at least 3 of the following parameters is designated with MetS: glucose intolerance, increased levels of triglycerides, augmented waist circumference, low levels of high-density lipoprotein cholesterol (HDL-c), and hypertension [,,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCacao Flavanol Exercise Performance Randomized Trial
claimIt is possible to develop a close relationship with MetS, metabolic dysfunction-associated steatotic liver disease (MASLD), and CVD [,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCacao Flavanol Exercise Performance Randomized Trial
claimMASLD is strongly associated with various conditions, including MetS, and is characterized by the persistence of a chronic inflammatory state detrimental to the organism [,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors
topicCacao Flavanol Exercise Performance Randomized Trial
claim1 2 3 4 5 6 7 8 9 10 11 12 13 14 Metabolic disorders are increasing sharply due to severe modifications in lifestyle [,,,].
evidence level3
citationTomaru Júlia Mayumi (2026)
sourceBeyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors