topicBranched Chain Amino Acids Resistance Exercise Meta-Analysis
claimDysregulated BCAA metabolism during aging, especially due to reduced BCKDH activity, can lead to the accumulation of toxic intermediates that impair insulin signaling and mitochondrial function (,).
evidence level3
citationWu Jing (2025)
sourceEffects of branched-chain amino acids on the muscle–brain metabolic axis: enhancing energy metabolism and neurological functions, and endurance exercise in aging-related conditions
topicBranched Chain Amino Acids Resistance Exercise Meta-Analysis
claimDisruption of BCKDH regulation or other defects in BCAA catabolism have been associated with elevated circulating BCAAs and altered metabolic signaling in aging and metabolic disease ().
evidence level3
citationWu Jing (2025)
sourceEffects of branched-chain amino acids on the muscle–brain metabolic axis: enhancing energy metabolism and neurological functions, and endurance exercise in aging-related conditions
topicBranched Chain Amino Acids Resistance Exercise Meta-Analysis
claimExperimental evidence indicates that targeted BCAA or leucine supplementation can support mitochondrial function and aspects of muscle bioenergetics in aging models, although effects depend on dose, duration, and context ().
evidence level3
citationWu Jing (2025)
sourceEffects of branched-chain amino acids on the muscle–brain metabolic axis: enhancing energy metabolism and neurological functions, and endurance exercise in aging-related conditions
topicBranched Chain Amino Acids Resistance Exercise Meta-Analysis
claim1–4 3 4 As the global population ages, maintaining physical and cognitive health has become a major public health priority.
evidence level3
citationWu Jing (2025)
sourceEffects of branched-chain amino acids on the muscle–brain metabolic axis: enhancing energy metabolism and neurological functions, and endurance exercise in aging-related conditions
topicBranched Chain Amino Acids Resistance Exercise Meta-Analysis
claimTo assess whether a low-protein vegan diet is associated with differences in recovery from exercise-induced muscle damage (EIMD) in physically active individuals.
evidence level4
citationMendes-Netto RS (2026)
sourceSimilar Muscle Recovery but Greater Soreness in Active Vegans on Low-Protein Diets Compared to High-Protein Omnivores Following Exercise-Induced Damage.
topicBranched Chain Amino Acids Resistance Exercise Meta-Analysis
claimProtein intake was significantly lower in vegans (0.98 g/kg) compared to omnivores (2.14 g/kg), along with reduced intake of essential amino acids and, specifically, branched-chain amino acids (p ≤ 0.05).
evidence level4
citationMendes-Netto RS (2026)
sourceSimilar Muscle Recovery but Greater Soreness in Active Vegans on Low-Protein Diets Compared to High-Protein Omnivores Following Exercise-Induced Damage.
topicBranched Chain Amino Acids Resistance Exercise Meta-Analysis
claimCK levels increased immediately after EIMD and peaked at 24 h, remaining elevated relative to baseline in both groups (p ≤ 0.05).
evidence level4
citationMendes-Netto RS (2026)
sourceSimilar Muscle Recovery but Greater Soreness in Active Vegans on Low-Protein Diets Compared to High-Protein Omnivores Following Exercise-Induced Damage.
topicBranched Chain Amino Acids Resistance Exercise Meta-Analysis
claimPhysically active vegans (n = 7) and omnivores (n = 7) underwent a lower-body muscle damage protocol consisting of five sets of repetitions to failure using the Smith machine squat and leg press at 85% of one-repetition maximum (1RM).
evidence level4
citationMendes-Netto RS (2026)
sourceSimilar Muscle Recovery but Greater Soreness in Active Vegans on Low-Protein Diets Compared to High-Protein Omnivores Following Exercise-Induced Damage.