topicBoron Bone Health Randomized Trial
claim1 2 1 2 Osteoporosis, the primary risk factor for fragility fractures, is highly prevalent and projected to increase as populations age globally [,].
evidence level1
citationTreister-Goltzman Yulia (2026)
sourceEffects of Prunes on Bone Density in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
topicBoron Bone Health Randomized Trial
claimFragility fractures, particularly of the hip, spine, and wrist, are associated with substantial morbidity, loss of independence, increased mortality, and considerable healthcare costs, making osteoporosis a significant public health concern [,].
evidence level1
citationTreister-Goltzman Yulia (2026)
sourceEffects of Prunes on Bone Density in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
topicBoron Bone Health Randomized Trial
claimEvidence from multiple in vitro biochemical and cell culture studies [,,], as well as preclinical investigations using ovariectomized and estrogen-deficient rodent models [,,,,,], consistently supports a favorable effect of prunes or prune-derived components on bone metabolism.
evidence level1
citationTreister-Goltzman Yulia (2026)
sourceEffects of Prunes on Bone Density in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
topicBoron Bone Health Randomized Trial
claimHowever, due to the limited number of human studies investigating the effects of vitamin D supplementation on implant outcomes, the current evidence remains weak and preliminary [,].
evidence level4
citationSodnom-Ish Buyanbileg (2026)
sourceThe effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review
topicBoron Bone Health Randomized Trial
claim10 Despite the recent growing interest and research insights, there is limited evidence on how the deficiency or supplementation of other micronutrients (e.g., boron, selenium, copper, or iron) influences osseointegration or the long-term implant survival and success.
evidence level4
citationSodnom-Ish Buyanbileg (2026)
sourceThe effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review
topicBoron Bone Health Randomized Trial
claimA previous review explored the effects of dietary supplements and nutraceuticals on dental implant osseointegration; however, most of the included studies were preclinical animal experiments with limited evidence from human research [].
evidence level4
citationSodnom-Ish Buyanbileg (2026)
sourceThe effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review
topicBoron Bone Health Randomized Trial
claim1 2 2 3 4 Since Brånemark’s groundbreaking discovery of osseointegration in the 1960s, the field of dental implantology has seen extensive scientific progress and innovation [].
evidence level4
citationSodnom-Ish Buyanbileg (2026)
sourceThe effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review