topicBlackcurrant Eye Fatigue Randomized Trial
claimThis systematic review aimed to evaluate randomized controlled trial (RCT) evidence on the effects of carotenoids, anthocyanins, polyunsaturated fatty acids, and combined nutraceutical formulations on refractive outcomes, axial length, macular pigment optical density (MPOD), visual function, and symptoms of visual fatigue.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicBlackcurrant Eye Fatigue Randomized Trial
claimEligible studies were RCTs involving individuals with myopia or at risk of myopia, comparing nutritional supplementation with placebo or active controls.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicBlackcurrant Eye Fatigue Randomized Trial
claimTwo reviewers independently screened studies, extracted data, and assessed risk of bias using the Cochrane RoB 2 tool.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicBlackcurrant Eye Fatigue Randomized Trial
claimBackground/objectives Nutritional supplementation has been proposed as a potential adjunct strategy in myopia prevention and control through antioxidative, anti-inflammatory, and extracellular matrix-regulating mechanisms.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicBlackcurrant Eye Fatigue Randomized Trial
claimIn addition to having a detrimental impact on everyday activities and quality of life, impaired vision also raises the likelihood of depression and disability in later life and can result in a loss of independence [,].
evidence level4
citationD’Angelo Angela (2025)
sourcePolyphenols and Eye Health: A Narrative Review of the Literature on the Therapeutic Effects for Ocular Diseases
topicBlackcurrant Eye Fatigue Randomized Trial
claimIncreasing evidence suggests that diet and specific nutrients may modulate these interconnected molecular networks, complementing standard pharmacological or surgical treatments and potentially slowing disease progression [,,].
evidence level4
citationD’Angelo Angela (2025)
sourcePolyphenols and Eye Health: A Narrative Review of the Literature on the Therapeutic Effects for Ocular Diseases
topicBlackcurrant Eye Fatigue Randomized Trial
claimFor example, key endogenous antioxidant pathways such as the Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2-related factor 2 (Keap1/Nrf2) signaling system, responsible for the transcription of protective enzymes like heme oxygenase-1 (HO-1), glutathione peroxidase, and superoxide dismutase (SOD), are often impaired in ocular pathology [].
evidence level4
citationD’Angelo Angela (2025)
sourcePolyphenols and Eye Health: A Narrative Review of the Literature on the Therapeutic Effects for Ocular Diseases
topicBlackcurrant Eye Fatigue Randomized Trial
claim1 2 3 4 Nowadays, one of the goals of the United Nations Summit on Sustainable Development is to improve eye health, which may be accomplished by including measures for care, prevention, promotion, and rehabilitation [].
evidence level4
citationD’Angelo Angela (2025)
sourcePolyphenols and Eye Health: A Narrative Review of the Literature on the Therapeutic Effects for Ocular Diseases