Structured evidence table for Black Seed Stress Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Black Seed Stress Randomized Trial | PCOS increases the risk of other disorders, including type 2 diabetes, dyslipidemia, high blood pressure, cancers, infertility, and metabolic diseases such as insulin resistance [,]. | 1 | Dashti Sareh (2026) | Herbal compounds in the treatment of polycystic ovary syndrome: an updated systematic review |
| Black Seed Stress Randomized Trial | 14 15 17 Conventional pharmacological interventions, such as hormonal contraceptives, insulin sensitizers, and ovulation-inducing agents are effective in symptom control, but may be associated with side effects, contraindications, or limited patient adherence []. | 1 | Dashti Sareh (2026) | Herbal compounds in the treatment of polycystic ovary syndrome: an updated systematic review |
| Black Seed Stress Randomized Trial | By consolidating recent findings, this review seeks to provide an evidence-based update to guide clinical practice and future research directions in integrating herbal therapies into PCOS management. | 1 | Dashti Sareh (2026) | Herbal compounds in the treatment of polycystic ovary syndrome: an updated systematic review |
| Black Seed Stress Randomized Trial | 1 3 4 5 5 6 7 Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and the most common cause of infertility due to lack of ovulation [–]. | 1 | Dashti Sareh (2026) | Herbal compounds in the treatment of polycystic ovary syndrome: an updated systematic review |
| Black Seed Stress Randomized Trial | Severity, frequency and duration of migraine attacks, headache daily result (HDR), quality of life, migraine disability, mental health, anthropometric indices, blood pressure, and serum levels of calcitonin gene-related peptide (CGRP), vascular cell adhesion molecules-1, total antioxidant capacity, and malondialdehyde were measured at baseline and end of the trial. | 2 | Eshaghian N (2025) | Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial. |
| Black Seed Stress Randomized Trial | Conclusion This study provides evidence supporting the beneficial effects of GSE supplement on the serum levels of CGRP. | 2 | Eshaghian N (2025) | Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial. |
| Black Seed Stress Randomized Trial | Background The current study was conducted to assess the effect of grape seed extract (GSE) supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in migraine patients. | 2 | Eshaghian N (2025) | Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial. |
| Black Seed Stress Randomized Trial | Materials and methods In this randomized double-blinded controlled clinical trial, 50 patients with migraine were randomly allocated to receive either 200 mg/day GSE supplement ( n = 25) or placebo ( n = 25) for 8 weeks. | 2 | Eshaghian N (2025) | Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial. |
Source documents