topicBlack Seed Skin Hydration Randomized Trial
claimNew evidence shows it amplifies oxidative stress via epigenetics in senescent cells [].
evidence level3
citationZhu Liangyu (2026)
sourcePlant-Derived Bioactive Compounds: Antioxidation, Autophagy, and Translational Applications in Skin Protection
topicBlack Seed Skin Hydration Randomized Trial
claimThis forms a “antioxidation→anti-inflammation→reduced ROS” virtuous cycle [].
evidence level3
citationZhu Liangyu (2026)
sourcePlant-Derived Bioactive Compounds: Antioxidation, Autophagy, and Translational Applications in Skin Protection
topicBlack Seed Skin Hydration Randomized Trial
claimIt reduces senescence-associated β-galactosidase (SA-β-gal)-positive cells.
evidence level3
citationZhu Liangyu (2026)
sourcePlant-Derived Bioactive Compounds: Antioxidation, Autophagy, and Translational Applications in Skin Protection
topicBlack Seed Skin Hydration Randomized Trial
claim1 2 3 Figure 1 4 5 6 7 8 9 10 10 The skin, as the body’s largest barrier organ, is constantly exposed to external aggressors such as ultraviolet radiation and environmental pollution, as well as intrinsic metabolic stress [,,].
evidence level3
citationZhu Liangyu (2026)
sourcePlant-Derived Bioactive Compounds: Antioxidation, Autophagy, and Translational Applications in Skin Protection
topicBlack Seed Skin Hydration Randomized Trial
claim1 inter alia Plump (or turgid) skin may be characterized as well-hydrated, firm, possessing a natural roundness and elasticity, and reflecting light in a manner associated with a radiant and youthful appearance—particularly in the facial area.
evidence level4
citationHavas Fabien (2026)
sourceHyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract
topicBlack Seed Skin Hydration Randomized Trial
claimConversely, decreased perceived skin plumpness is associated with increased apparent age [].
evidence level4
citationHavas Fabien (2026)
sourceHyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract
topicBlack Seed Skin Hydration Randomized Trial
claimThe other major collagen type in skin is collagen III; with fine, flexible fibers, it is also found in the dermis, and also plays a part in skin elasticity and structural integrity, and in wound healing, where it regulates matrix architecture and mechanosensing [,].
evidence level4
citationHavas Fabien (2026)
sourceHyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract