Structured evidence table for Black Seed Oil Lipid Profile Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Black Seed Oil Lipid Profile Randomized Trial | Increased dietary LA has contributed to a pervasive imbalance in dietary-6 relative to-3 polyunsaturated fatty acids (PUFA) that has been proposed to affect the incidence and progression of chronic diseases [,,]. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Black Seed Oil Lipid Profile Randomized Trial | 13 14 15 16 17 18 19 20 n n n n n n Early guidance to increase dietary LA stemmed from the diet–heart hypothesis of the 1960s–1970s, which proposed that replacing saturated fats with LA-rich vegetable oils would lower serum cholesterol, thereby reducing the risk of atherosclerosis and coronary heart disease. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Black Seed Oil Lipid Profile Randomized Trial | A re-analysis of the Sydney Diet Heart Study showed that replacing saturated fat with high-LA safflower oil markedly increased all-cause and cardiovascular mortality despite lowering cholesterol []. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Black Seed Oil Lipid Profile Randomized Trial | 1 2 3 4 5 6 7 8 9 10 11 12 n n n Over the past century, shifts in agricultural practices toward the industrial production of commodity crops, particularly soybeans and corn, have transformed the global food supply and sparked a scientific and public health debate [,,,]. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Black Seed Oil Lipid Profile Randomized Trial | Additionally, the risk of disease development is significantly increased by comorbidities such as obesity, type 2 diabetes, and metabolic syndrome []. | 3 | Fic Weronika (2026) | Thymoquinone in Atherosclerosis: A Multi-Target Nutraceutical Modulating Inflammation, Oxidative Stress, and Lipid Metabolism |
| Black Seed Oil Lipid Profile Randomized Trial | Excessive enlargement of the necrotic core relative to the thickness of the fibrous cap increases the risk of plaque rupture and thrombus formation []. | 3 | Fic Weronika (2026) | Thymoquinone in Atherosclerosis: A Multi-Target Nutraceutical Modulating Inflammation, Oxidative Stress, and Lipid Metabolism |
| Black Seed Oil Lipid Profile Randomized Trial | This study was conducted as a narrative review, the aim of which was to critically analyze the available scientific evidence regarding the role of TQ in modulating processes associated with atherosclerosis development, with a particular focus on inflammation, oxidative stress, and lipid metabolism disorders. | 3 | Fic Weronika (2026) | Thymoquinone in Atherosclerosis: A Multi-Target Nutraceutical Modulating Inflammation, Oxidative Stress, and Lipid Metabolism |
| Black Seed Oil Lipid Profile Randomized Trial | 1 2 3 2 3 4 5 5 6 2 In recent years, a significant increase in the prevalence of chronic cardiovascular diseases (CVD) has been reported in both developed and developing countries. | 3 | Fic Weronika (2026) | Thymoquinone in Atherosclerosis: A Multi-Target Nutraceutical Modulating Inflammation, Oxidative Stress, and Lipid Metabolism |
Source documents