Structured evidence table for Black Seed Metabolic Wellness Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Black Seed Metabolic Wellness Meta-Analysis | Increased dietary LA has contributed to a pervasive imbalance in dietary-6 relative to-3 polyunsaturated fatty acids (PUFA) that has been proposed to affect the incidence and progression of chronic diseases [,,]. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Black Seed Metabolic Wellness Meta-Analysis | 13 14 15 16 17 18 19 20 n n n n n n Early guidance to increase dietary LA stemmed from the diet–heart hypothesis of the 1960s–1970s, which proposed that replacing saturated fats with LA-rich vegetable oils would lower serum cholesterol, thereby reducing the risk of atherosclerosis and coronary heart disease. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Black Seed Metabolic Wellness Meta-Analysis | A re-analysis of the Sydney Diet Heart Study showed that replacing saturated fat with high-LA safflower oil markedly increased all-cause and cardiovascular mortality despite lowering cholesterol []. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Black Seed Metabolic Wellness Meta-Analysis | 1 2 3 4 5 6 7 8 9 10 11 12 n n n Over the past century, shifts in agricultural practices toward the industrial production of commodity crops, particularly soybeans and corn, have transformed the global food supply and sparked a scientific and public health debate [,,,]. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Black Seed Metabolic Wellness Meta-Analysis | Evidence shows substantial heterogeneity in symptom prevalence and interpretation, shaped by ethnicity [], social norms, stigma, and access to information and care []. | 3 | Muacevic Alexander (2026) | Complementary and Alternative Medicine in the Management of Perimenopausal Sleep Disturbances: A Scoping Review |
| Black Seed Metabolic Wellness Meta-Analysis | During perimenopause, declining estrogen and progesterone levels can alter neurotransmitter activity, thermoregulation, and arousal thresholds, contributing to insomnia, nighttime awakenings, and reduced sleep efficiency [,,]. | 3 | Muacevic Alexander (2026) | Complementary and Alternative Medicine in the Management of Perimenopausal Sleep Disturbances: A Scoping Review |
| Black Seed Metabolic Wellness Meta-Analysis | These disturbances are associated with adverse health outcomes and diminished quality of life (QoL) [,]. | 3 | Muacevic Alexander (2026) | Complementary and Alternative Medicine in the Management of Perimenopausal Sleep Disturbances: A Scoping Review |
| Black Seed Metabolic Wellness Meta-Analysis | 1 2 3 5 Menopause marks a major physiological transition in women’s lives, defined by the permanent cessation of menstruation following the depletion of ovarian follicles and a decline in estrogen production. | 3 | Muacevic Alexander (2026) | Complementary and Alternative Medicine in the Management of Perimenopausal Sleep Disturbances: A Scoping Review |
Source documents