evidence table

Black Seed Blood Pressure Randomized Trial Evidence Table

Structured evidence table for Black Seed Blood Pressure Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Black Seed Blood Pressure Randomized TrialSeverity, frequency and duration of migraine attacks, headache daily result (HDR), quality of life, migraine disability, mental health, anthropometric indices, blood pressure, and serum levels of calcitonin gene-related peptide (CGRP), vascular cell adhesion molecules-1, total antioxidant capacity, and malondialdehyde were measured at baseline and end of the trial.2Eshaghian N (2025)Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
Black Seed Blood Pressure Randomized TrialConclusion This study provides evidence supporting the beneficial effects of GSE supplement on the serum levels of CGRP.2Eshaghian N (2025)Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
Black Seed Blood Pressure Randomized TrialBackground The current study was conducted to assess the effect of grape seed extract (GSE) supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in migraine patients.2Eshaghian N (2025)Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
Black Seed Blood Pressure Randomized TrialMaterials and methods In this randomized double-blinded controlled clinical trial, 50 patients with migraine were randomly allocated to receive either 200 mg/day GSE supplement ( n = 25) or placebo ( n = 25) for 8 weeks.2Eshaghian N (2025)Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
Black Seed Blood Pressure Randomized TrialSome of these phytochemicals are unique to specific H/S, for example, piperine is exclusively found in black pepper, while cinnamaldehyde and coumarin are only found in cinnamon.3Huang Yudai (2026)Phytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes
Black Seed Blood Pressure Randomized TrialAlternatively, other phytochemicals are found in different amounts in a variety of H/S, such as hydroxycinnamic acids and hydroxybenzoic acids, presenting in both the Italian herb mixture and cinnamon.3Huang Yudai (2026)Phytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes
Black Seed Blood Pressure Randomized TrialTerpenoids were only found in the Italian herb mixture, with a concentration of 498.6 ± 29.9 mg per 100 g.3Huang Yudai (2026)Phytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes
Black Seed Blood Pressure Randomized TrialHerbs and spices (H/S) have been utilized as folk medicine in different parts of the world for centuries and have significance in cultural, religious and traditional healing practices.3Huang Yudai (2026)Phytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes
topicBlack Seed Blood Pressure Randomized Trial
claimSeverity, frequency and duration of migraine attacks, headache daily result (HDR), quality of life, migraine disability, mental health, anthropometric indices, blood pressure, and serum levels of calcitonin gene-related peptide (CGRP), vascular cell adhesion molecules-1, total antioxidant capacity, and malondialdehyde were measured at baseline and end of the trial.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicBlack Seed Blood Pressure Randomized Trial
claimConclusion This study provides evidence supporting the beneficial effects of GSE supplement on the serum levels of CGRP.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicBlack Seed Blood Pressure Randomized Trial
claimBackground The current study was conducted to assess the effect of grape seed extract (GSE) supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in migraine patients.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicBlack Seed Blood Pressure Randomized Trial
claimMaterials and methods In this randomized double-blinded controlled clinical trial, 50 patients with migraine were randomly allocated to receive either 200 mg/day GSE supplement ( n = 25) or placebo ( n = 25) for 8 weeks.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicBlack Seed Blood Pressure Randomized Trial
claimSome of these phytochemicals are unique to specific H/S, for example, piperine is exclusively found in black pepper, while cinnamaldehyde and coumarin are only found in cinnamon.
evidence level3
citationHuang Yudai (2026)
sourcePhytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes
topicBlack Seed Blood Pressure Randomized Trial
claimAlternatively, other phytochemicals are found in different amounts in a variety of H/S, such as hydroxycinnamic acids and hydroxybenzoic acids, presenting in both the Italian herb mixture and cinnamon.
evidence level3
citationHuang Yudai (2026)
sourcePhytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes
topicBlack Seed Blood Pressure Randomized Trial
claimTerpenoids were only found in the Italian herb mixture, with a concentration of 498.6 ± 29.9 mg per 100 g.
evidence level3
citationHuang Yudai (2026)
sourcePhytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes
topicBlack Seed Blood Pressure Randomized Trial
claimHerbs and spices (H/S) have been utilized as folk medicine in different parts of the world for centuries and have significance in cultural, religious and traditional healing practices.
evidence level3
citationHuang Yudai (2026)
sourcePhytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes

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Source documents

  1. Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
  2. Phytochemicals From Herbs and Spices: Their Absorption, Metabolism, and Relationship to Clinical Outcomes